神经系统相关蛋白及基因二级数据库的构建

神经分子生物学的深入研究,生成了海量数据,神经系统相关蛋白及基因的数据搜集和整理势在必行。以NCBI和RCSB维护的一级数据库作为核酸序列、蛋白质序列和蛋白质结构信息来源,设计新的数据模型,建立本地二级数据库。该数据库基于Sun Blade 2000系统,以Oracle 9i作为后台软件,所有应用程序基于Java进行开发。其中,采用Web信息自动获取及XML技术,实现序列信息的搜集和数据库提交;使用JSP JavaBean技术实现数据库网站发布。该数据库的构建为研究神经分子生物学和相关疾病的致病机理提供了一个良好的平台。

Construction of Nervous System Relative Protein and Gene Secondary Database

Along with the rapid research of neural molecular biology,abundant data are produced so that the collection and coordination of high-throughout data about nervous system relative proteins and genes are imperative.Through analyzing the biological primary databases maintained by NCBI and RCSB as the main data source and designing a new data model,a local specialized secondary database is constructed,which mainly includes nucleotide sequences,protein sequences and protein structures,and is established on Sun Blade 2000 System and Oracle 9i. All programs are developed by Java technology.A method of web information automatic retrieval with XML is proposed for sequence data collection and submission to the database.JSP JavaBean technology is used to support data promulgation on Internet.The establishment of this database provides an excellent platform for the research of neural molecular biology and the pathogenesis of related diseases.