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| 基质细胞衍生因子-1及其受体CXCR4在肿瘤转移中的作用 | |
| 引用本文： | 陈宏远,谭毅,蔡绍晖,马伟峰,郭芝刚,杜军,蔡绍皙. 基质细胞衍生因子-1及其受体CXCR4在肿瘤转移中的作用[J]. 生物医学工程学杂志, 2007, 24(5): 1180-1183 |
| 作者姓名： | 陈宏远 谭毅 蔡绍晖 马伟峰 郭芝刚 杜军 蔡绍皙 |
| 作者单位： | 1. 重庆大学,生物工程学院,国家教育部生物力学与组织工程重点实验室,重庆,400044 2. 重庆大学,生物工程学院,国家教育部生物力学与组织工程重点实验室,重庆,400044;暨南大学,药学院,临床药理教研室,广州,510632 3. 暨南大学,药学院,临床药理教研室,广州,510632 4. 中山大学,药学院,广州,510612 |
| 基金项目： | 国家自然科学基金;国家重点实验室基金 |
| 摘 要： | 基质细胞衍生因子-1(Stromal cell-derived factor-1,SDF-1)及其受体CXCR4与人类多种肿瘤转移密切相关,CXCR4在一些肿瘤细胞系、原发肿瘤组织均呈高表达。SDF-1在肿瘤细胞潜在转移靶器官的表达量比非常规转移靶器官高,肿瘤细胞利用CXCR4与其天然配体间的趋化效应实现远距离转移。SDF-1/CXCR4驱动癌细胞转移模式的提出及其相互作用机制的深入研究对于肿瘤治疗具有重要的指导意义。 |
| 关 键 词： | 基质细胞衍生因子-1 肿瘤 肿瘤转移 |
| 修稿时间： | 2005-05-13 |
The Role of SDF-1 and Its Receptor CXCR4 in Tumor Metastasis |
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| Chen Hongyuan,Tan Yi,Cai Shaohui,Ma Weifeng,Guo Zhigang,Du Jun,Cai Shaoxi. The Role of SDF-1 and Its Receptor CXCR4 in Tumor Metastasis[J]. Journal of biomedical engineering, 2007, 24(5): 1180-1183 | |
| Authors: | Chen Hongyuan Tan Yi Cai Shaohui Ma Weifeng Guo Zhigang Du Jun Cai Shaoxi |
| Affiliation: | Key Laboratory for Biomechanics & Tissue Engineering of the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. |
| Abstract: | The chemokine SDF-1(CXCL12) and its receptor,CXCR4,have been implicated in organ-specific metastases of several malignancies.CXCR4 expression has recently been characterized in many cancer cell types and is thought to play a pivotal role in directing the migration of metastasizing tumor cells to SDF-1rich tissues.SDF-1,which is highly expressed in the organs where breast cancers preferentially metastasize,has been shown to promote cancer cell migration.The tumor cells use chemotaxis which occurred between CXCR4 and its ligand SDF-1 to direct migration from their primary sites via the circulation to the preferential sites of metastases,and further studies on the mechanism involved in a variety of cellular signaling pathways are beneficial to tumor therapy. |
| Keywords: | CXCR4 |
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