| 人巨细胞病毒融合蛋白pp150/MDBP二级结构及其抗原表位预测 |
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| 引用本文： | 郭大东,高雪芹,韩金祥.人巨细胞病毒融合蛋白pp150/MDBP二级结构及其抗原表位预测[J].生物医学工程学杂志,2007,24(5):1123-1127. |
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| 作者姓名： | 郭大东 高雪芹 韩金祥 |
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| 作者单位： | 国家卫生部,生物技术药物重点实验室,山东省医药生物技术研究中心,济南,250062 |
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| 摘 要： | 用Garnier-Robson和Chou-Fasman方案预测人巨细胞病毒融合蛋白pp150/MDBP的α-螺旋、β-折叠及转角的二级结构,用Kyte-Doolittle及Hopp-Woods亲水性方案预测其B细胞表位。研究结果表明,pp150/MDBP融合蛋白可能含有较少的α-螺旋,但可能含有较多的β-折叠及转角;B细胞识别的表位可能在7~56氨基酸残基或附近以及137~192残基或附近。
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| 关 键 词： | 人巨细胞病毒 融合蛋白 二级结构 表位 预测 |
| 修稿时间： | 2005-05-19 |
Predication of Secondary Structures and Epitopes of Fusion Protein pp150/MDBP |
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| Guo Dadong,Gao Xueqin,Han Jinxiang.Predication of Secondary Structures and Epitopes of Fusion Protein pp150/MDBP[J].Journal of Biomedical Engineering,2007,24(5):1123-1127. |
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| Authors: | Guo Dadong Gao Xueqin Han Jinxiang |
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| Institution: | Key Laboratory for Biotech-drugs, Ministry of Health Shandong Medicinal Biotechnology Centre, Ji'nan 250062, China. |
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| Abstract: | The secondary structures of fusion protein pp150/MDBP, including alpha-helix, beta-sheet, turn regions, were analyzed by Garnier-Robson's and Chou-Fasman's methods; the antigenic epitopes of B cells were analysed by using hydrophilicity plot. The results showed that the fusion protein pp150/MDBP might have less alpha-helix, but be rich in beta-sheet and turn regions. The epitopes recognized by B cells may be at 7-56 amino acid residues or adjacent to 137-192 amino acid residues. |
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| Keywords: | Human cytomegalovirus(HCMV) Fusion protein Secondary structure Epitope Prediction |
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