Free-radical status of human blood leukocytes during hyperbaric exposure |
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| Authors: | A. V. Bizyukin E. A. Ostrakhovich D. O. Meshkov A. V. Vdovin A. G. Chuchalin |
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| Affiliation: | (1) Institute of Pulmonology, Ministry of Health, Moscow;(2) Institute of Vitamins; Institute of Biomedical Problems, Ministry of Health, Moscow;(3) P. P. Shirshov Institute of Oceanology, Russian Academy of Sciences, Moscow |
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| Abstract: | Submerging in a pressure chamber to a depth of up to 250 m was simulated in a 22-day experiment. The production of active oxygen forms in the blood leukocytes of divers was studied. The production of superoxide radical was 5–12 times decreased in the leukocytes stimulated with phorbol myristate acetate, which may be due to a 2- to 3-fold decrease in NADPH oxidase activity. A 5-fold increase in the ratio of luminol to lucigenin chemiluminescence indicates that production of active oxygen forms is shifted towards the forms other than superoxide. Increased incidence of infectious diseases in the divers after long deep submerging may result from disorders in primary nonspecific immunity in the presence of phagocytosing blood cells. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 211–214, August, 1997 |
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| Keywords: | active oxygen forms superoxide radical leukocytes hyperbaric exposure oxygen-helium environment |
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