| 曲马多药物树脂缓释混悬剂人体药动学研究 |
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| 引用本文： | 张志燕,平其能.曲马多药物树脂缓释混悬剂人体药动学研究[J].中国药科大学学报,2000,31(4):20-23. |
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| 作者姓名： | 张志燕 平其能 |
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| 作者单位： | 张志燕（中国药科大学药剂学教研室，南京210009）
平其能（中国药科大学药剂学教研室，南京210009） |
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| 基金项目： | 本研究为国家“九五”攻关资助项目(96-902-02-05) |
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| 摘 要： | 制备曲马多药物树脂缓释混悬剂，以市售普通胶囊剂为对照，研究了缓释混悬剂的药物动力学和生物利用度。采用ＨＰＬＣ法测定两制剂血药浓度，结果表明，４种健康志愿者单剂量口服缓释混悬剂１０ｍｌ一，达峰时间明显后移，峰浓度显著降低，以血药浓度经时曲线下面积计算相对生物利用度为１０３．５％，两制剂生物等效。
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| 关 键 词： | 盐酸曲马多 药物树脂 缓释混悬剂 药物动力学 |
Pharmacokinetic Study of Tramadol-resinate Sustained-release Suspension in Healthy Volunteers |
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| ZHANG Zhi-Yan,PING Qi-Neng.Pharmacokinetic Study of Tramadol-resinate Sustained-release Suspension in Healthy Volunteers[J].Journal of China Pharmaceutical University,2000,31(4):20-23. |
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| Authors: | ZHANG Zhi-Yan PING Qi-Neng |
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| Institution: | ZHANG Zhi-Yan
,PING Qi-Neng
(Department of Pharmaceutics, China Pharmaceutical University, Nan jing 210009) |
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| Abstract: | s Tramadol resinate sustained release suspension was prepared. Compared with normal tramadol capsule, the pharmacokinetics of sustained release suspension was evaluated. The serum concentration of tramadol was deternined by HPLC method. The results revealed that T max was significantly delayed to 5.18 h and C max was much lower(301.46 ng/ml) than corresponding value of normal capsule(386.02 ng/ml).The relative bioavailability of the suspension was 103.5% compared with normal capsule. |
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| Keywords: | Tramadol Drug-resinate Sustained-release Dissolution in vitro Pharmacokinetics |
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