| PDGF在子宫内膜癌中的表达及其与血管生成的关系 |
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| 引用本文： | Shuang Chen Caigang Liu （Co-first author） Yonglai Wang Song Gao. PDGF在子宫内膜癌中的表达及其与血管生成的关系[J]. 中德临床肿瘤学杂志, 2008, 7(10): 597-599. DOI: 10.1007/s10330-008-0104-1 |
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| 作者姓名： | Shuang Chen Caigang Liu （Co-first author） Yonglai Wang Song Gao |
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| 摘 要： | Objective:To investigate the expression of platelet-derived endothelial growth factor(PDGF) and its effect in angiogenesis in endometrial cancer(EC),in order to investigate the mechanism of tumorigenesis and lay a foundation for the management of EC.Methods:We selected 40 cases with EC,20 endometrium,and 20 normal endometrium.All specimens were stained immunohistochemically for CD34 and PDGF identified immunohistochemically with specific antibodies.Results:The expression of PDGF was significantly higher in EC than normal endometrium and atypical hyperplasia of endometrium(P < 0.05),however,no significant difference was found between normal endometrium and atypical hyperplasia of endometrium(P > 0.05).The expression of PDGF was lower in well differentiated than moderately and poorly differentiated EC(P < 0.05).In cases with muscular invasion tumors,it was higher than in normal endometrium(P < 0.05).After Spearman correlation analysis,MVD was significantly influenced by PDGF,r = 0.848(P = 0.000).Conclusion:There was positive correlation between microvessel density(MVD) and PDGF in earlier stage of EC,it illustrate that PDGF may take part in angiogenesis of EC.
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| 关 键 词： | PDGF 临床分析 子宫内膜癌 基因表达 血管生成 |
| 收稿时间： | 2010-07-22 |
The relationship between PDGF and angiogenesis in endometrial cancer |
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| Shuang Chen,Caigang Liu,Yonglai Wang,Song Gao. The relationship between PDGF and angiogenesis in endometrial cancer[J]. The Chinese-German Journal of Clinical Oncology, 2008, 7(10): 597-599. DOI: 10.1007/s10330-008-0104-1 |
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| Authors: | Shuang Chen Caigang Liu Yonglai Wang Song Gao |
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| Affiliation: | Co-first author |
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| Abstract: | Objective: To investigate the expression of platelet-derived endothelial growth factor (PDGF) and its effect in angiogenesis in endometrial cancer (EC), in order to investigate the mechanism of tumorigenesis and lay a foundation for the management of EC. Methods: We selected 40 cases with EC, 20 endometrium, and 20 normal endometrium. All specimens were stained immunohistochemically for CD34 and PDGF identified immunohistochemically with specific antibodies. Results: The expression of PDGF was significantly higher in EC than normal endometrium and atypical hyperplasia of endometrium (P < 0.05), however, no significant difference was found between normal endometrium and atypical hyperplasia of endometrium (P > 0.05). The expression of PDGF was lower in well differentiated than moderately and poorly differentiated EC (P < 0.05). In cases with muscular invasion tumors, it was higher than in normal endometrium (P < 0.05). After Spearman correlation analysis, MVD was significantly influenced by PDGF, r = 0.848 (P = 0.000). Conclusion: There was positive correlation between microvessel density (MVD) and PDGF in earlier stage of EC, it illustrate that PDGF may take part in angiogenesis of EC. |
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| Keywords: | endometrial cancer (EC) immunohistochemistry microvessel density (MVD) platelet-derived endothelial growth factor (PDGF) |
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