| 辛伐他汀对慢性血栓栓塞性肺动脉高压患者血浆PAI-1的影响 |
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| 引用本文： | 侯鲁静,王枫岭. 辛伐他汀对慢性血栓栓塞性肺动脉高压患者血浆PAI-1的影响[J]. 医药论坛杂志, 2011, 0(2): 82-84 |
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| 作者姓名： | 侯鲁静 王枫岭 |
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| 作者单位： | 郑州市二砂医院内科;河南省胸科医院心内科 |
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| 摘 要： | 目的探讨辛伐他汀对慢性血栓栓塞性肺动脉高压(chronic thromboembolic pulmonary hypertension,CTEPH)患者血浆纤溶酶原激活物抑制剂-1(plasminogen activator inhibitor-1,PAI-1)活性的影响。方法 CTEPH患者分别服用10、20、40mg/天辛伐他汀7、14、21d后,用PAI-1发色底物法检测血浆PAI-1活性。结果与对照组相比,CTEPH组血浆PAI-1水平明显增高;辛伐他汀呈剂量依赖性降低CTEPH患者血浆PAI-1水平。结论辛伐他汀可降低CTEPH患者血浆PAI-1水平。
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| 关 键 词： | 辛伐他汀 慢性血栓栓塞性肺动脉高压 纤溶酶原激活物抑制剂-1 |
Effects of simvastatin to PAI-1 activity in chronic thromboembolic pulmonary hypertension patients |
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| HOU Lu-jing,WANG Feng-ling. Effects of simvastatin to PAI-1 activity in chronic thromboembolic pulmonary hypertension patients[J]. Journal of Medical Forum, 2011, 0(2): 82-84 |
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| Authors: | HOU Lu-jing WANG Feng-ling |
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| Affiliation: | Hospital of Zhengzhou the 2nd Abrasion Wheel Factory,Zhengzhou 450006,China |
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