Anti-ischemic effect of a new oxynicotinic acid derivative |
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| Authors: | T V Ryasina T S Korshunova N B Polyanskii K O Muranov |
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| Institution: | (1) Institute of Neurology, Russian Academy of Medical Sciences, Moscow;(2) N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow |
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| Abstract: | The effect of a new derivative of oxynicotinic acid (KONA) on experimental cerebral ischemia is examined in rats. It is demonstrated
that a single dose of the preparation (30 mg/kg) significantly decreases the severity of ischemic damage and increases the
survival of the animals after bilateral ligation of the common carotid arteries. Comparison with xanthinol-nicotinate shows
the advantages of the new preparation. Although KONA does not inhibit free-radical oxidationin vitro, it does lower the content of free-radical oxidation products in rat blood plasma to the normal level.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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7, pp. 49–51, July, 1994
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences |
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| Keywords: | cerebral ischemia nicotinic acid derivatives lipid peroxidation |
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