泡状棘球蚴病16例临床病理学及免疫组化观察

目的:探讨泡状棘球蚴病临床病理学及免疫组化特征。方法:对16例泡状棘球蚴病变组织切片进行CD20、CD3、CD45RA、CD45RO、CD5染色,部分病例做了EMA、CD68、CK标记。结果:泡状棘球蚴病见于肝、脑、肺、胰腺和淋巴结等器官,免疫组化结果提示病变内散在浸润淋巴细胞中有T细胞和B细胞,泡球囊肿内生发上皮与角质膜不表达CK和EMA,增生的组织细胞表达CD68和EMA。结论:泡状棘球蚴病诊断依赖病理活检,术前穿刺活检或术中冰冻切片检查是行之有效的诊断方法。消灭传染源,切断传播途径综合防治该病。

Clinic pathological and immunohistochemical observation of echinococcosis alveolaris in 16 cases

Objective:To investigate the clinic pathological and immunohistochemical features of echinococcosis(alveolaris)(EA).Methods: All of 16 cases of EA sections were observed by light microscope and stained with CD20,CD3,CD45RA,CD45RO,CD5 EMA,CD68 and CKp,respectively by immunohistochemical method.(Results:) The lesions of EA were found in liver,brain,lung,pancreas and lymph nodes.The results of(immunohistochemical) staining showed that there were dispersed infiltration of T and B lymph cells in the lesions and germinative epithilium and keratious membrane of alveoli were negative for EMA and CKp.The EMA and CD68 were positively expressied in proliferated histocytes.Conclusion: The diagnosis of EA depends on the biopsy and pathological examination.The puncture biopsy and freeze section examination before and during operation are very useful and effective methods for the diagnosis of the disease.