院前急救中胺碘酮治疗快速心房纤颤的疗效分析

目的：比较胺碘酮和毛花甙C（西地兰）静脉用药治疗院前急救中快速心房纤颤的疗效。方法：随机抽取2010年1月-2011年1月上海市医疗急救中心随车急救中用毛花甙C治疗心房纤颤的110例病例为Ⅰ组；2011年2月-2013年2月用胺碘酮治疗心房纤颤的110例病例为Ⅱ组。Ⅰ组静脉注射毛花甙C 0.4～0.8 mg。Ⅱ组静脉注射胺碘酮150 mg,如未转复为窦性心律者,重复给予75～150 mg，后改为静脉滴注150～450 mg。结果：胺碘酮组治疗效果优于毛花甙C组，两组差异有统计学意义。结论：静脉注射胺碘酮治疗心房纤颤的作用迅速、安全,其疗效优于毛花甙C。

Analysis of the efifcacy of amiodarone for the treatment of rapid atrial ifbrillation in pre-hospital emergency care

Objective：To compare the efifcacy of amiodarone and lanatoside C（cedilanid） in the intravenous treatment of rapid atrial fibrillation at the pre-hospital emergency center. Methods： One hundred and ten cases of patients with atrial ifbrillation treated with lanatoside C were randomly selected as group I in Shanghai Medical Emergency Center ambulance during Jan. 2010-Jan. 2011 while another 110 cases treated with amiodarone as group II during Feb. 2011-Feb. 2013. 0.4~0.8 mg of lanatoside C was intravenously given in group I and 150 mg of amiodarone in group II, and 75~150 mg of amiodarone were repeatedly given and then 150~450 mg of amiodarone if the patients did not convert to sinus rhythm. Results：The efifcacy of amiodarone was better than that of lanatoside C, and the difference was statistically signiifcant. Conclusion：Amiodarone in the treatment of atrial ifbrillation possesses quick action and good safety and its efifcacy is much better than lanatoside C. So it is recommended as the ifrst choice for the treatment of fast atrial ifbrillation in pre-hospital emergency.