国产亮丙瑞林与手术去势治疗前列腺癌的疗效比较

目的：比较晚期前列腺癌患者分别采用国产亮丙瑞林药物去势与手术去势治疗的疗效和安全性。方法：60例患者随机采用国产亮丙瑞林药物去势或手术去势，并联合比卡鲁胺行全雄激素阻断，观察两种治疗方法的疗效及不良反应。结果：药物去势组与手术去势组的有效率分别为86.6%和83.3%（P〉0.05），90%药物去势和93%手术去势患者的血清睾酮水平经6个月治疗后维持在去势水平。两组治疗相关不良反应主要表现为潮热、乳房胀痛、疲劳等，两组无统计学差异，但注射部位疼痛为药物去势所特有。结论：国产亮丙瑞林药物去势与手术去势相比，短期疗效确切，不良反应小，能改善患者的生活质量。

Clinical comparative study on domestic leuprorelin and surgical castration for the treatment of prostate cancer

Objective： To compare the effectiveness and safety of domestic leuprorelin medical castration and surgical castration in patients with prostate cancer. Methods：Sixty patients were randomly divided into a medical castration group and a surgical castration group and meanwhile received bicalutamide for the blockade of total androgen. Efifcacy and adverse reaction were compared between two groups. Testosterone concentrations, prostate-speciifc-antigen and treatment-related adverse events were recorded. Results：The effective rate was 86.6%in the medical castration group and 83.3%in the surgical castration group （P〉0.05）. Plasma testosterone concentration of 90%patients in the medical castration group and 93%patients in the surgical castration group was remained in the level of castration after 6-month treatment. The adverse events related to the treatment appeared as hot lfash, swollen breast, fatigue and hyperhidrosis with insigniifcant difference though injection-site pain was special for medical castration. Conclusion：As compared with surgical castration, medical castration with domestic leuprorelin has a veriifed short-term efifcacy, less adverse reaction and can improve the life quality of patients.