垂体后叶素联合酚妥拉明治疗支气管扩张大咯血的临床效果分析

目的 分析垂体后叶素联合酚妥拉明治疗支气管扩张大咯血的临床效果.方法 回顾性选取100例支气管扩张大咯血患者,依据治疗方法不同分为常规治疗组和联合治疗组,各50例.常规治疗组患者给予常规治疗,联合治疗组在常规治疗基础上给予垂体后叶素联合酚妥拉明治疗.比较两组患者的临床疗效,治疗前后的生命体征、经皮血氧饱和度,出血天数、...

Clinical effect of pituitrin combined with phentolamine in the treatment of bronchiectasis and massive hemoptysis

Objective To analyze the clinical effect of pituitrin combined with phentolamine in treatment of bronchiectasis and massive hemoptysis.Methods 100 patients with bronchiectasis and massive hemoptysis were retrospectively selected and divided into routine treatment group and combined treatment group based on their therapeutic methods,with 50 cases in each group.Patients in the routine treatment group received the routine treatment,and patients in the combined treatment group received pituitrin combined with phentolamine in addition to the routine treatment.The clinical efficacy,vital signs,percutaneous oxygen saturation,bleeding days,total bleeding volume and adverse reactions before and after the treatment were compared between the two groups.Results The overall efficacy of the combined treatment group was 92.0%(46/50),which was significantly higher than 74.0%(37/50) of the routine treatment group,and the difference was statistically significant(P<0.05).Before the treatment,the combined treatment group had the body temperature of(38.6±1.4) ℃,respiratory rate of(43.5±7.2) times/min,heart rate of(115.2±14.3) times/min,diastolic blood pressure of(55.2±9.2) mm Hg(1 mm Hg = 0.133 kPa),systolic blood pressure of(85.2±11.2) mm Hg and percutaneous oxygen saturation of(60.5±14.7)%;after the treatment,the combined treatment group had the body temperature of(36.8±1.2)℃,respiratory rate of(29.6±5.5) times/min,heart rate of(85.2±10.1) times/min,diastolic blood pressure of(80.5±10.5) mm Hg,systolic blood pressure of(110.3±10.3) mm Hg and percutaneous oxygen saturation of(95.3±13.5)%.Before the treatment,the routine treatment group had the body temperature of(38.3±1.9)℃,respiratory rate of(44.3±7.5) times/min,heart rate of(114.4±13.7) times/min,diastolic blood pressure of(55.0±9.5) mm Hg,systolic blood pressure of(86.3±11.5) mm Hg and percutaneous oxygen saturation of(61.5±14.9)%;after the treatment,the routine treatment group had the body temperature of(37.3±1.2)℃,respiratory rate of(34.2±5.6) times/min,heart rate of(94.3±11.8) times/min,diastolic blood pressure of(66.5±9.7) mm Hg,systolic blood pressure of(95.3±10.4) mm Hg and percutaneous oxygen saturation of(85.5±12.6)%.Before the treatment,the differences in body temperature,respiratory rate,heart rate,diastolic blood pressure,systolic blood pressure and percutaneous oxygen saturation between the two groups were not statistically significant(P>0.05).After the treatment,the body temperature,respiratory rate and heart rate of each group were lower than those before the treatment,the diastolic pressure,systolic pressure and percutaneous oxygen saturation were higher than those before the treatment,and the differences were statistically significant(P<0.05).After the treatment,the body temperature,respiratory rate and heart rate of the combined treatment group were lower than those of the routine treatment group,and the diastolic blood pressure,systolic blood pressure and percutaneous oxygen saturation of the combined treatment group were significantly higher than those of the routine treatment group,and the differences were statistically significant(P<0.05).The bleeding days of the combined treatment group was(7.0±1.2) d,which was significantly shorter than(10.4±1.5) d of the routine treatment group,and the total bleeding volume of the combined treatment group was(730.7±156.5) ml,which was significantly less than(906.8±140.0) ml of the routine treatment group;and the differences were statistically significant(P<0.05).The incidence of adverse reactions of the combined treatment group was 8.0%(4/50),which was significantly lower than 24.0%(12/50) of the routine treatment group.Conclusion Pituitrin combined with phentolamine has good clinical effects in the treatment of bronchiectasis and massive hemoptysis.