基于Roy适应模式的护理干预对重症狼疮性肾炎患者肾功能、免疫功能及生命质量的影响

目的 探究基于Roy适应模式的护理干预应用于重症狼疮性肾炎（LN）的临床效果。方法 选取2018年1月—2020年6月医院收治的78例重症LN患者，按照组间基线资料匹配的原则分为对照组和观察组，每组39例。对照组给予常规护理，观察组采用Roy适应模式护理。比较干预前后两组的肾功能、免疫功能及生命质量。结果 干预前，两组肾功能指标、免疫功能指标及生活质量综合评定问卷GQOLI-74评分的比较差异均无统计学意义（P>0.05）。干预后，观察组24 h尿蛋白定量、血肌酐(Scr)、红细胞沉降率(ESR)水平低于对照组，差异有统计学意义（P<0.05）；与对照组比，观察组抗双链DNA(ds-DNA)、补体C3水平高，抗核抗体（ANA）滴度、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)低，差异有统计学意义（P<0.05）；干预后，观察组GQOLI-74物质生活状态、心理功能、社会功能维度的评分高于对照组，差异有统计学意义（P<0.05）。结论 为重症LN患者提供Roy适应模式护理能取得较好的临床效果，促进患者肾功能改善，调节免疫功能，提高患者生命...

Effects of nursing intervention based on Roy adaptation mode on renal function immune function and quality of life in patients with severe lupus nephritis

Objective To explore the clinical ef fect of nursing intervention based on Roy adaptation mode in severe lupus nephritis(LN). Methods A total of 78 patients with severe LN admitted in the hospital from January 2018 to June 2020 were selected and divided into a control group and an observation group according to the principle of basic data matching between groups, with 39 cases in each group. The control group was given routine nursing, the observation group was given Roy adaptation mode nursing. The renal function, immune function and quality of life of the two groups were compared before and after intervention. Results Before intervention,there was no signifi cant dif ference in renal function index, immune function index and GQOLI-74 score of the comprehensive assessment questionnaire between two groups(P>0.05). After intervention, the levels of 24 h urine protein, serum creatinine(Scr) and erythrocyte sedimentation rate(ESR) in the observation group were lower than the control group, the dif ferences were statistically signifi cant(P<0.05). Compared with the control group, the levels of anti-double-stranded DNA(DS-DNA) and complement C3 were higher in the observation group, the titers of anti-nuclear antibody(ANA), immunoglobulin A(IgA), immunoglobulin G(IgG) and immunoglobulin M(IgM)were lower in the observation group, the dif ferences were statistically signifi cant(P<0.05). After intervention,the scores of material life status, psychological function and social function of GQOLI-74 in the observation group were higher than the control group, the differences were statistically significant(P<0.05). Conclusion Roy adaptation mode nursing for the severe patients with LN could achieve good clinical effect, promote the improvement of renal function, regulate immune function and improve the quality of life of patients.