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慢性阻塞性肺疾病伴认知功能障碍患者血清lipocalin-2表达及意义
引用本文:朱成华,蔡璐,安伯萍,杜强. 慢性阻塞性肺疾病伴认知功能障碍患者血清lipocalin-2表达及意义[J]. 中华肺部疾病杂志(电子版), 2022, 15(1): 29-32. DOI: 10.3877/cma.j.issn.1674-6902.2022.01.007
作者姓名:朱成华  蔡璐  安伯萍  杜强
作者单位:1. 210011 江苏,南京医科大学第二附属医院呼吸科2. 210011 江苏,南京医科大学第二附属医院内分泌科
基金项目:江苏省六大人才高峰项目(WSN-015)。
摘    要:目的分析血清脂质运载蛋白-2(lipocalin-2)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)稳定期伴认知障碍患者血清中的表达变化及其意义。 方法依据蒙特利尔认知评估量表(Montreal cognitive assessment, MoCA)评分,MoCA分值<26分者为认知受损,将43例COPD稳定期的患者分为认知障碍组23例及认知正常组20例,并选取20例健康体检者做对照组;采用酶联免疫吸附实验(ELISA)分别检测患者外周静脉血清脂质运载蛋白-2(lipocalin-2)水平;分析血清脂质运载蛋白-2与认知功能的相关性,根据血清lipocalin-2水平预测认知障碍的受试者工作特征(ROC)曲线。 结果与健康对照组相比(60.37±10.77)μg/ml,COPD稳定期伴认知障碍患者血清lipocalin-2水平(82.76±12.90)μg/ml显著增加(P<0.05);与COPD稳定期认知正常组(69.70±11.51)μg/ml相比,认知功能障碍组血清lipocalin-2水平显著升高,差别有统计学意义(P<0.05)。Pearson相关分析结果显示血清lipocalin-2水平与MoCA评分呈负相关(r=-0.749,P<0.001);血清lipocalin-2水平预测COPD稳定期患者认知功能障碍的ROC曲线下面积分别为0.804(95%CI 0.664~0.945,P<0.001)。 结论血清lipocalin-2表达水平与COPD稳定期患者认知功能障碍密切相关。血清lipocalin-2水平检测可能成为COPD患者出现认知功能障碍的一个重要诊断指标。

关 键 词:肺疾病,慢性阻塞性  认知功能  蒙特利尔认知评估量表  脂质运载蛋白-2  
收稿时间:2021-10-25

Expression and Significance of Serum lipocalin-2 in Patients with chronic obstructive pulmonary disease with Cognitive Impairment
Zhu Chenghua,Cai Lu,An Boping,Du Qiang. Expression and Significance of Serum lipocalin-2 in Patients with chronic obstructive pulmonary disease with Cognitive Impairment[J]. Chinese Journal of lung Disease(Electronic Edition), 2022, 15(1): 29-32. DOI: 10.3877/cma.j.issn.1674-6902.2022.01.007
Authors:Zhu Chenghua  Cai Lu  An Boping  Du Qiang
Affiliation:1. Department of Respiratory Medicine, the second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China2. Department of Endocrinology Medicine, the Second Affiliated Hospital of Nanjing Medical university, Nanjing, 210011, China
Abstract:Objective To investigate the correlation and clinical significance of serum lipocalin-2 level with cognitive impairment in patients with the stable stage of chronic obstructive pulmonary disease(COPD).Methods According to the Montreal cognitive assessment(MoCA)scale standard for evaluation,a cutoff score of<26 defined as mild cognitive impairment(MCI).A total of 43 patients in the stable stage of COPD were divided into a cognitive impairment group(Cog I)(23 patients)and a cognitive normal group(Cog N)(20 patients),and 20 healthy Subjects as control group.The level of serum lipocalin-2 in each group was detected by enzyme-linked immunosorbent assay(ELISA),the correlation between lipocalin-2 and cognitive function was analyzed,and the ROC curve of cognitive impairment was predicted according to the level of lipocalin-2.Results Compared with the healthy control group(60.37±10.77)μg/ml,the serum level of lipocalin-2 in stable COPD patients with cognitive impairment(82.76±12.90)μg/ml was significant higher(P<0.05).Compared with than the cognitive normal group(69.70±11.51)μg/ml,the protein level of lipocalin-2 was increased in serum of stable COPD patients with cognitive impairment(P<0.05).Pearson line correlation revealed that the serum level of lipocalin-2 was negatively correlated with MoCA score(r=-0.749,P<0.001),The areas under ROC curve of serum lipocalin-2 level to predict cognitive dysfunction in the COPD patients was 0.804(95%CI 0.664-0.945,P<0.001).Conclusion The serum lipocalin-2 level is closely related to the cognitive dysfunction of stable COPD patients.The detection of serum lipocalin-2 level may be an important diagnostic index of cognitive dysfunction in COPD patients.
Keywords:Chronic obstructive pulmonary disease  Cognitive function  Montreal cognitive assessment  lipocalin-2
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