奥卡西平与左乙拉西坦联合阿昔洛韦治疗单纯性疱疹病毒性脑炎继发癫痫患儿的效果比较

目的:比较奥卡西平与左乙拉西坦联合阿昔洛韦治疗单纯性疱疹病毒性脑炎继发癫痫患儿的效果。方法:选取80例单纯性疱疹病毒性脑炎继发癫痫患儿为研究对象,按随机数字表法将其分为观察组(n=40)和对照组(n=40)。对照组采用左乙拉西坦片联合注射用阿昔洛韦治疗,观察组采用奥卡西平片联合注射用阿昔洛韦治疗,比较两组治疗前后血清炎性因子白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)]水平、临床疗效、血清脑源性神经营养因子(BDNF)和血清神经元特异性烯醇化酶(NSE)水平,以及不良反应发生率。结果:治疗后,观察组IL-1β、IL-6和TNF-α水平均低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为95.00%,高于对照组的80.00%,差异统计学意义(P<0.05);观察组BDNF水平高于对照组,NSE水平低于对照组,差异统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P<0.05)。结论:奥卡西平片联合注射用阿昔洛韦治疗单纯性疱疹病毒性脑炎继发癫痫患儿可提高治疗总有效率和BDNF水平,以及降低炎性因子水平和NSE水平,其效果优于左乙拉西坦片联合注射用阿昔洛韦治疗。

Comparison of effects of Oxcarbazepine and Levetiracetam combined with Acyclovir in treatment of children with epilepsy secondary to herpes simplex virus encephalitis

Objective:To compare effects of Oxcarbazepine and Levetiracetam combined with Acyclovir in treatment of children with epilepsy secondary to herpes simplex virus encephalitis.Methods:80 children with epilepsy secondary to herpes simplex viral encephalitis were selected as the research objects,and were divided into observation group(n=40)and control group(n=40)according to the random number table method.The control group was treated with Levetiracetam tablets combined with Acyclovir for injection,while the observation group was treated with Oxcarbazepine tablets combined with Acyclovir for injection.the levels of serum inflammatory factorsinterleukin-1β(IL-1β),serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)],the clinical efficacy,the serum brain-derived neurotrophic factor(BDNF)levels and the serum neuron-specific enolase(NSE)levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of IL-1β,IL-6 and TNF-αin the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 95.00%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).The BDNF level of the observation group was higher than that of the control group;the NSE level was lower than that of the control group;and the difference was statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusions:Oxcarbazepine tablets combined with Acyclovir for injection in the treatment of the children with epilepsy secondary to herpes simplex viral encephalitis can increase the total effective rate of treatment and the BDNF level,and reduce the levels of inflammatory factors and the NSE level.Moreover,it is superior to Levetiracetam tablets combined with Acyclovir for injection.