拟诺卡菌感染1例并文献复习

目的 了解拟诺卡菌感染的临床特征及诊治方案.方法 对1例拟诺卡菌所致皮肤感染的患者资料进行分析.以"拟诺卡菌"为主题词检索万方、维普和中国知网数据库,以"Nocardiopsis"为主题词检索PubMed数据库,获取文献报道的拟诺卡菌所致感染的病例,筛选并总结分析病例资料.结果 福建医科大学附属泉州第一医院报道的1例病...

Nocardiosis:a case report and literature review

Objective To understand the clinical characteristics and treatment of nocardiosis.Methods The clinical data of a case of skin infection caused by Nocardia was analyzed.Wanfang,VIP,CNKI,and PubMed databases were searched using“Nocardiopsis”as the search term.The cases of nocardiosis reported at home and abroad were reviewed.Results The patient reported in Quanzhou First Hospital Affiliated to Fujian Medical University had multiple lumps on the left arm due to a fishbone stab,and was diagnosed as skin nocardiosis.After treatment with trimethoprim-sulfamethoxazole for 5 months,the patient largely recovered.Eight cases of nocardiosis,including the one reported here,were reviewed retrospectively.The clinical manifestation included skin infection in 4 cases,disseminated infection in 2 cases,lung infection and nasal infection in one case each.Three of the 4 patients with skin infection got the infection following injury by potato fork,toothpick,and fish bone,respectively.The other 4 patients might be infected due to poor immunity.Three patients with skin infection were cured following treatment with trimethoprim-sulfamethoxazole.The other five patients received different treatments.Finally,one patient died.All the other patients were cured.Conclusions Nocardia can colonize in a variety of environments,and cause infection after skin stabbing.Clinical diagnosis depends on molecular biological methods.It is not advisable to use cephalosporin empirically for treatment of nocardiosis.Trimethoprim-sulfamethoxazole is recommended as the first choice for the treatment of nocardiosis.