基于影像学危险因素评价化疗对于减少中高危腹膜后神经母细胞瘤手术并发症的作用研究

目的 基于影像学危险因素(image-defined risk factor,IDRF)概念,探讨化疗对于减少中高危腹膜后神经母细胞瘤手术并发症的作用.方法 回顾性分析2016年6月至2017年6月在首都医科大学附属北京儿童医院行规范化疗后完整切除肿瘤的中高危腹膜后神经母细胞瘤患儿临床及影像学资料.采用国际神经母细胞瘤...

Evaluation of chemotherapy for reducing operative complications of medium and high risk retroperitoneal neuroblastoma based on imaging-defined risk factor

Objective To research the role of neoadjuvant chemotherapy in reducing operative complications of medium and high risk retroperitoneal neuroblastoma based on the concept of imaging-defined risk factor(IDRF).Methods The whole clinical and surgical data of children with medium and high risk retroperitoneal neuroblastoma who underwent standardized chemotherapy and surgery from June 2016 to June 2017 in Beijing Children's Hospital were retrospectively analyzed.IDRF were defined according to the international neuroblastoma risk group(INRG)standard.Changes in IDRF during diagnosis and treatment were recorded.We compared IDRF before and after chemotherapy in each patient.The correlation between the number of preoperative IDRF and the number of surgical complications was analyzed by spearman correlation coefficient method(P value<0.05 was statistically significant).Results A total of 53 cases were collected,including 22 boys and 31 girls.The age of onset ranged from 4 to 148 months,with an average of 39.60±28.70 months.The number of IDRFs ranged from 0 to 11(median 4 items)before chemotherapy and from 0 to 11(median 3 items)after chemotherapy.The change of IDRFs had statistical significance(P<0.05).A total of 74 complications occurred in 37 patients,with a maximum of 4 complications and a minimum of 0 complications(median of 1 complications)in each patient.There was a strong correlation between the number of operative complications and the number of preoperative IDRFs(r=0.687,P<0.05).Conclusion Chemotherapy can effectively reduce IDRF and surgical risk.IDRF is of great value in the assessment of surgical risk.