清肺健脾法治疗湿热证持续性变应性鼻炎疗效观察

目的 观察清肺健脾法治疗湿热证持续性变应性鼻炎的即刻和远期疗效及对免疫炎性因子的影响.方法 将2016年11月—2018年5月在首都医科大学附属北京同仁医院治疗的80例湿热证持续性变应性鼻炎患者随机分为2组,治疗组给予清肺健脾治法中药颗粒剂口服,对照组给予氯雷他定片口服,2组均治疗4周.观察2组治疗前、治疗4周后、治疗...

Observation on the curative effect of clearing lung and invigorating spleen in the treatment of persistent allergic rhinitis with damp-heat syndrome

Objective It is to observe the immediate and long-term efficacy of Qingfei Jianpi method in the treatment of persistent allergic rhinitis with damp-heat syndrome and its effect on immune inflammatory factors. Methods Eighty patients with persistent allergic rhinitis with damp-heat syndrome treated in Beijing Tongren Hospital Affiliated to Capital Medical University from November 2016 to May 2018 were randomly divided into two groups. The treatment group was given Chinese medicine granules for clearing lung and invigorating spleen orally, the control group was given loratadine tablets orally, both groups were treated for 4 weeks. The changes in the symptom score, Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ) scores, and the levels of serum immunoglobulin E(IgE), interleukin-4(IL-4), interleukin-5(IL-5) and interferon-γ(IFN-γ) were observed before treatment, after 4 weeks of treatment, and 16 weeks after treatment in the two groups. The immediate efficacy after 4 weeks of treatment and the long-term efficacy in 16 weeks after treatment were compared between the two groups, and the safety of the two groups was evaluated. Results 39 cases in the treatment group and 38 cases in the control group completed the study. After 4 weeks of treatment, the symptom scores, RQLQ scores, and the levels of serum IgE and IL-5 in both groups were significantly lower than those before treatment(P all<0.05), and the level of serum IFN-γ in the treatment group was significantly higher than that before treatment(P<0.05), but there was no significant difference in each index between the two groups(all P>0.05). In 16 weeks after the end of treatment, there were no significant differences in symptom scores, RQLQ scores and serum levels of IgE, IL-4, IL-5 and IFN-γ in the control group compared with those before treatment(all P>0.05);the symptom scores and RQLQ score in the treatment group were significantly lower while serum IFN-γ levels were significantly higher than those before treatment and in the control group at the same period(P all<0.05), there was no significant difference in the levels of serum IgE, IL-4 and IL-5 compared with those before treatment and in the control group at the same period(all P>0.05). After 4 weeks of treatment, the total effective rate was 87.2%(34/39) in the treatment group and 76.3%(29/38) in the control group, there was no significant difference between the two groups(P>0.05). In 16 weeks after treatment, the total effective rate in the treatment group was 76.9%(30/38), and 44.7%(17/38) in the control group, there was a statistically significant difference between the two groups(P<0.05). No adverse reactions was found in both groups. Conclusion Qingfei Jianpi method is effective and safe in the treatment of persistent allergic rhinitis, especially in the follow-up period, it shows better effect than western medicine, it has the effect of continuous stabilization of symptoms and improvement of quality of life, which may be related to reducing IgE and correcting Th1/Th2 cell imbalance.