尿激酶对急性脑梗死患者血浆纤溶酶活性变化的研究

目的观察尿激酶(UK)治疗急性脑梗死的疗效及血浆纤溶酶的活性变化。方法对起病<6h,或起病超过6h、但小于12h,CT证实的25例脑梗死患者静推UK30万U,静滴UK50万U,总量<200万U;对治疗前后患者的神经功能缺损进行评定,并检测血浆D二聚体和纤溶酶活性的水平。结果治疗后患者的临床症状明显改善,血浆D二聚体及纤溶酶活性明显升高(P<0.01或P<0.001)。结论UK溶栓治疗急性脑梗死疗效好且安全。

Clinical Investigation of Urokinase in Acute Cerebral Infarction Plasm Fibrinolysin Ofresult

Objective To observe the clinical and fibrinolytic effect o f Urokinase(UK)therapy in the acute cerebral infarction,and alteration of D-dimer concentrations and plasmin activity.Methods:25cases suffered from cerebral infa rction by CT scan,<6 hours or >6 hours and <12 hours after the onset of ischemic stroke,using UK by 300 thouseand unit intravenously and 500 thousand unit intra venous injection.Total dosage is <2000 thousand unit.After treatment,the scale o f neurological deficit was used for functional assessment;Plasma fibrin D-dimer levels and plasmin activity was measured.Results:Patients obtain improvement( P<0.01 or P<0.001).Conclusion:Thrombolytic therapy of using UK in the earl y cerebral infarction is positive effect and safety.