Reye and Reye-like Syndromes: Result of a Pilot Stud in Peninsular Malaya, 1986 |
| |
Authors: | D. Sinniah R. Sinniah Y. F. Yap Mahinder Singh R. George N. L. Lim S. Balakrishnan F. D'Cruz Wan Ariffin Pyar Kaur T. C. Yeo Jai Mohan S. Yogeswary M. Paranjothy |
| |
Affiliation: | *Department of Paediatrics, Faculty of Medicine, University of Malaya;General Hospitals, Kuala Lumpur;Johore Bahru;Alor Setar;Ipoh;Kelang;Assunta Hospital, Petaling Jaya;Universiti Sains Malaysia, Kubang Kerian;Department of Pathology, National University of Singapore. |
| |
Abstract: | A pilot epidemiologic study of all cases of Reye and Reye-like syndromes was undertaken at 8 representative major hospitals in Peninsular Malaya from January 1st to December 31st 1986. The cases were classified as definitive Reye's syndrome, clinical Reye's syndrome and encephalo-hepatopathies. Less than 50% of cases reviewed fulfined the National Center for Disease Control criteria for clinical Reye's syndrome. Causes of Reye-like syndromes/encephalo-hepatopathies included fulminant hepatitis, Japanese B encephalitis, dengue, septicaemia, and complex febrile fits. It was not possible to differentiate clinical Reye's syndrome from the other encephalo-hepatopathies by either the clinical features (except for jaundice) or biochemical parameters. Liver biopsy is necessary for a definitive diagnosis of Reye's syndrome in Malaysia, because of the high prevalence of Reye-like diseases. The mortality rate in the 2 groups of patients is similar. Ingestion of salicylates was not found to be significantly associated with Reye and Reye-like syndromes in this study. |
| |
Keywords: | Reye's syndrome, Reye-like syndrome, Encephalo-hepathopathies |
|
|