药物联合治疗幽门螺杆菌阳性消化性溃疡52例观察

目的：观察奥美拉唑，阿莫西林和甲哨唑联合搭配，疗程和剂量的效果来探索理想治疗幽门螺杆菌（Hp)的方案，方法：Hp阳性的十二指肠溃疡40例，胃溃疡12例随机分成治疗组和对照组，观察记录Hp根除，溃疡愈合，临床症状改善情况及复发率。结果：两组比较，溃疡愈合率治疗组为96％，对照组88．9％，差异无显著性（P＞0．05）;Hp根除率治疗组为80％，对照组7．4％，差异非常显著（P＜0．005），结论：奥美拉唑，阿莫西林和甲哨唑联合14d治疗方案具有药物量小，疗程短，疗效高，副反应小，价格适宜等特点，是较为理想的根除Hp，治愈溃疡，降低溃疡复发率的方案。

Observation of Drug Combination in Treatment of 52 Cases with Peptic Ulcer Positive in Pylorus Helicobacterium(Hp)

Objective To explore a method for treating Hp by observing the curative effects of a combination of omeprazole,amoxicillin and metronidazole in conditions of different proportions,courses and doses.Methods 40.cases with duodenal ulcers and 12 cases with gastric ulcers,both positive in Hp,were randomly divided into two groups,A and B. Group A was treated with the drug combination. Group B ,as a contrast,was given only omeprazole. .Eradication of Hp,ulcer healing,symptom improvement and recurrence rate were observed and recorded.Results Ulcer healing in Group A accounted for 96%,while 88.9% in Group B,not great in difference,(P>0.05). Eradication of Hp was 80% and 7.4% respectively in Group A and Group B,greatly different in results,(P<0.005).Conclusion 14-day course of treatment with the combination of omeprazole,amoxicillin,and metronidazole shows the following advantages: less in dosage,short in course,high in curative effects,low in side effects and proper in drug prices. Therefore,the combination is a satisfactory method for eradication of Hp,ulcer healing and reduction of ulcer recurrence rate.