乳腺癌中树突状细胞浸润的临床意义

目的 :探讨乳腺癌中肿瘤浸润性树突状细胞 (TIDC)与肿瘤发生发展的关系及对患者预后的影响。方法 :用免疫组化法 (S -P法 )检测 5 8例乳腺癌中树突状细胞浸润程度及ER的表达 ,其中 30例检测PCNA表达 ,分析TIDC与PCNA、ER表达的关系。进行随访并以COX模型做生存分析。结果 :树突状细胞浸润与PCNA表达呈负相关 ,r=- 0 .6 96 ,肿瘤不同组织学分级及不同ER状况的TIDC浸润有显著性差异 ,TIDC浸润影响患者预后。结论 :TIDC抑制乳腺癌细胞的增殖并影响其分化状况 ,可作为评估乳腺癌预后的因素之一。

Clinical Significance of Infiltration of Dendritic Cells in Breast Cancer

Objective To study the relationship between tumor infiltration dendritic cells and the breast cancer cells' proliferation and differentiation,and to probe their relations to prognosis. Methods The breast cancer tissue was examined immunohistochemically for DC infiltration and expression of PCNA and ER,and the data were analysed according to chi-square test,t-test,regression,correlation and cox model. Results The tumor infiltration of DC(TIDC) in highly differentiated cell carcinoma was obviously higher than that of moderately and low differentiated ones(P<0.05). Negative correlation existed between TIDC and expression of PCNA(r=-0.696). The tumors with ER positive expression were highly infiltrated with DC than that of negative ones(P<0.01). Cox model indicated patients with higher TIDC lived longer than those with lower ones(P<0.05). Conclusion TIDC seems to influence proliferation and differentiation of the breast cancer cells. It should act as a positive prognostic factor.