序贯疗法与标准三联疗法治疗幽门螺杆菌的临床疗效比较

目的：研究序贯疗法与标准三联疗法治疗幽门螺杆菌的临床疗效。方法选取幽门螺杆菌阳性患者120例，按照数字表法将患者分为A组和B组，每组60例。 A组给予序贯疗法（奥美拉唑＋阿莫西林治疗5 d以后继续以奥美拉唑＋克拉霉素＋替硝唑治疗5 d）治疗，B组给予标准三联疗法（奥美拉唑＋阿莫西林＋克拉霉素）治疗，比较两组幽门螺杆菌根除率、溃疡愈合总有效率以及不良反应。结果 A组幽门螺杆菌的根除率91．7％（55／60），显著高于对照组的71．7％（43／60）（χ^2＝11．915，P＝0．023）；A组溃疡愈合总有效率96．7％（58／60），显著高于B组的88．3％（53／60）（χ^2＝9．915，P＝0．038）；两组不良反应发生率差异无统计学意义（χ^2＝4．735，P＝0．072）。结论序贯疗法相比标准三联疗法治疗幽门螺杆菌具有较好的效果，能显著提高幽门螺杆菌的根除率，且无严重不良反应。

Comparison of clinical therapeutic effect of sequential therapy and standard triple therapy for Helicobacter pylori

Objective To study the clinical effects of sequential therapy and standard triple therapy for Helicobacter pylori.Methods 120 cases with positive Helicobacter pylori were divided into A group and B group according to the number table method,60 cases in each group.A group received sequential therapy （ omeprazole＋amoxicillin treatment after 5 days continue to omeprazole clarithromycin and metronidazole treatment for 5 days）,B group received standard triple therapy （ omeprazole ＋amoxicillin ＋clarithromycin ） , eradication rate of Helicobacter pylori,the total efficiency of ulcer healing and adverse reaction of the two groups were compared.Results The eradication rate of Helicobacter pylori of group A was 91.7%（55/60）,which was significantly higher than 71.7%（43/60） of group B （χ^2 =11.915,P=0.023）;the ulcer healing and the total effective rate of group A was 96.7%（58/60）,which was significantly higher than 88.3%（53/60） of group B,the difference was statistically significant （χ^2 =9.915,P=0.038）;there was no statistically significant difference between the two groups in adverse reaction （χ^2 =4.735,P=0.072）.Conclusion Sequential therapy has a better effect in treatment Helicobacter pylori than the standard triple therapy, which can significantly improve the eradication of Helicobacter pylori, with no serious adverse reactions.