| 刺梨及其有效成分抗肿瘤效应研究 |
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| 引用本文： | 石玉城,倪红梅,梁光义.刺梨及其有效成分抗肿瘤效应研究[J].中国中西医结合杂志,1998(Z1). |
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| 作者姓名： | 石玉城 倪红梅 梁光义 |
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| 作者单位： | 贵阳中医学院 贵阳550002 |
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| 基金项目： | 贵州省卫生厅资助课题(黔卫90014) |
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| 摘 要： | 目的:探讨刺梨及其有效成分抗肿瘤作用。方法:以刺梨浸膏观察用药后荷瘤小鼠的抑瘤率、生命延长率,以6种成分观察体外瘤细胞生长抑制率。结果:刺梨浸膏以每日900mg/kg 灌胃14天,对 H_(22)移植瘤抑制率平均为52.9%;刺梨6种成分体外实验表明,其中 R_5、R_6两种成分对 H_(22)瘤细胞有明显的抑制作用,浓度在100μg/ml 时,抑瘤率分别为81.4%、100%;对荷 H_22瘤小鼠生命有一定延长作用。结论:刺梨有明显的抗肿瘤作用,其抗肿瘤有效成分为 R_5和 R_6。
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| 关 键 词： | 刺梨及其有效成分 抑瘤效应 体内实验 体外实验 |
Study on the Anti-Tumor Effect of Fractus Rosae Normalis and Its Effective Components |
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| Authors: | Shi Yucheng Ni Hongmei Liang Guangyi Guiyang College of TCM Guiyang |
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| Abstract: | Objective:To study the anti-tumor action of Fractus Rosae Normalis(FRN) and its effective components.Methods: The tumor-inhibiting rate,life-prolonging rate and growth-inhibiting rate of the tumor bearing mice were determined af- ter administering FRN extract and its six effective components.Results:When FRN extract was administered to the mice with transplanted H_(22) tumor cell by gastrogavage in a dosage of 900 mg/kg daily for 14 days,the tumor-inhibiting rate was 52.9% on average.Tests in vitro with six effective components of FRN revealed R_5 and R_6 of the six components have remarkable inhibiting action on H_(22) tumor cells.When their concentration was 100 (g/ml,the tumor-inhibiting rates were 81.4% and 100% respectively,which shows they have the effect of prolonging the life of mice with H_(22) tumor to some degree.Conclusion:FRN has remarkable anti-tumor effect.Its effective anti-tumor components are R_5 and R_6. |
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| Keywords: | Fractus Rosae Normalis effective components of Fractus Rosae Normalis tumor-inhibiting effect test in vivo test in vitro |
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