妊高征胎盘功能变化及其与胎儿预后关系的探讨

测定妊高征患者尿E/C比值、血SP_1值、HPL值及PZP值,旨在探讨妊高征患者的胎盘功能变化及其对胎儿预后的影响。结果表明,妊高征患者尿E/C比值、血SP_1及HPE值随病变加重而逐渐下降,当其低值时,低Apgar评分及低体重儿的发生率明显增加(P<0.01);但PZP下降幅度不明显,并与胎儿预后无明显关系。多指标联合测定表明,当E/C比值、血SP_1和HPL值均低时,低Apgar评分的发生率可达83.3％,低体重儿的发生率可达66.7％。据此认为,监测妊高征患者胎盘功能的变化,对预测胎儿预后有重要的参考价值,若能进行多指标测定分析则可提高判定胎儿预后的准确性。

Study of pregnancy induced hypertension and its relationship with fetal prognosis

This paper reported that urinary estrogen/creatinine(E/C),serum pregnancy specific beta 1 glycoprotein(SP1),human placental lactogen(hPL) ,and pregnancy zone protein(PZP)levels were determined in 136 cases with pregnancy induced hypertesion (PIH), which studied placental function of PIH to have an influence on fetal prognosis. The results indicated that E/C ratio,SP1, hPL and PZP levels in patient with PIH decreased with serious degree of PIH,incidence of their low values increased gradually with serious degree of PIH, but PZP levels of them had no obvious change. While E/C ratio,SP1,and hPL were low values,incidence of low Apgar score and low birth weight increased significantly ( P<0.01),but serum PZP levels had no significance. Analysis of many indices indicated that while E/C ratio, SP1 and hPL levels were all low values, low Apgar score and low birth weight might be 83. 3% and 66. 7%,respectively. This study have shown that measurment E/C ratio,serum SP1 and hPL levels may be a better index for monitoring PIH,detecting placental function and evaluating fetal prognosis.