Malignancy probability map as a novel imaging biomarker to predict malignancy distribution: employing MRS in GBM patients |
| |
| Authors: | Manijeh Beigi Kevan Ghasemi Parvin Mirzaghavami Mohammadreza Khanmohammadi Hamidreza SalighehRad |
| |
| Affiliation: | 1.Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Institute for Advanced Medical Imaging,Tehran University of Medical Sciences,Tehran,Iran;2.Department of Medical Physics and Biomedical Engineering,Tehran University of Medical Sciences,Tehran,Iran;3.Medical Physics Department, Faculty of Medicine,Iran University of Medical Sciences,Tehran,Iran;4.Chemistry Department, Faculty of Science,Imam Khomeini International University,Qazvin,Iran |
| |
| Abstract: | The main aim of this study was to propose a new statistical method for evaluation of spatial malignancy distribution within Magnetic Resonance Spectroscopy (MRS) grid in Glioblastoma Multiforme patients. Voxels with different malignancy probabilities were presented as a novel MRS-based Malignancy Probability Map (MPM). For this purpose, a predictive probability-based clustering approach was developed, including the two following steps: (1) Gaussian Mixture Model, (2) Quadratic Discriminate Analysis coupled with Genetic Algorithm. Clustered probability values from two methods were then integrated to exploit the MPM. Results show that the suggested method is able to estimate the malignancy distribution with over 90% sensitivity and specificity. The proposed MRS-based MPM has an acceptable accuracy for providing useful complementary information about regional diffuse glioma malignancy, with the potential to lead to better detection of tumoral regions with high probability of malignancy. So, it also may encourage the use of additional information of this map as a tool for dose painting. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
