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重齿毛当归(独活)中异当归醇、毛当归醇及其它香豆素的分离与鉴定
引用本文:潘竞先,LAMY,K,ARISON,B,SMITH,J,韩桂秋.重齿毛当归(独活)中异当归醇、毛当归醇及其它香豆素的分离与鉴定[J].药学学报,1987,22(5):380-384.
作者姓名:潘竞先  LAMY  K  ARISON  B  SMITH  J  韩桂秋
作者单位:北京医科大学药学院;*MerckSharp&DohmeResearchLaboratories,USA
摘    要:Nine coumarins were isolated from dichloromethane extract of the roots of Angelica pubescens Maxim. Seven of them were identified as osthol (Ⅰ), columbianetin acetate (Ⅱ), columbianetin (Ⅲ), bergapten (Ⅳ), angelol (Ⅴ),xanthotoxin (Ⅵ) and isoimperatorin (Ⅶ). (Ⅵ) and (Ⅶ) were isolated for the first time from this plant. Two new coumarins were elucidated as isoangelol (Ⅷ), a geometric isomer of angelol C20H24O7 α]D20-133.5 and anpubesol C20H26O7 α]D20 -72.5 on the basis of spectral evidences.

关 键 词:重齿毛当归  香豆素  异当归醇  毛当归醇
收稿时间:1986-07-29

ISOLATION AND [DENTIFTCATION OF ISOANGELOL, ANPUBESOL AND OTHER COUMARINS FROM ANGELICA PUBESCENS MAXIM
PAN Jing-Xian,LAM YK,ARISON B,SMITH J and HAN Gui-Qiu.ISOLATION AND [DENTIFTCATION OF ISOANGELOL, ANPUBESOL AND OTHER COUMARINS FROM ANGELICA PUBESCENS MAXIM[J].Acta Pharmaceutica Sinica,1987,22(5):380-384.
Authors:PAN Jing-Xian  LAM YK  ARISON B  SMITH J and HAN Gui-Qiu
Abstract:Nine coumarins were isolated from dichloromethane extract of the roots of Angelica pubescens Maxim. Seven of them were identified as osthol (Ⅰ), columbianetin acetate (Ⅱ), columbianetin (Ⅲ), bergapten (Ⅳ), angelol (Ⅴ),xanthotoxin (Ⅵ) and isoimperatorin (Ⅶ). (Ⅵ) and (Ⅶ) were isolated for the first time from this plant. Two new coumarins were elucidated as isoangelol (Ⅷ), a geometric isomer of angelol C20H24O7 α]D20-133.5 and anpubesol C20H26O7 α]D20 -72.5 on the basis of spectral evidences.
Keywords:Coumarins  Isoangelol  Anpubesol  Angelica pubescens
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