Restriction fragment length polymorphisms on the q24–q28 region of X chromosome among Japanese population

Restriction fragment length polymorphisms were studied among the Japanese population using 12 polymorphic DNA probes on the q24–q28 region of X chromosome. The frequency distribution for probes p22–33, p482.6a, p43–15, 52A, pPM101, cX33.2 and cpx234, was the same as that for Caucasians, and that for probes 4D-8 and St14-1 (MspI) was slightly different (p<0.05). however,="" it="" was="" quite="" different=""><0.01) for="" probes="" p114.12,="" st14-1="">TaqI), 36B-2 and MN12. Probe p114.12 showed noHindIII polymorphism for the Japanese people. On the contrary, probe MN12, which has a low PIC value (0.15) for Caucasians, was found to be useful for Japanese (PIC value=0.50). These results suggest that 7 DNA probes (p482.6a, p43–15, 52A, St14-1, p114.12 (BclI), 36B-2 and MN12) are useful (PIC>0.42) for linkage analysis of X-linked disease in Japan.