脊髓再灌注损伤的临床诊断及围手术期处理

目的总结脊髓再灌注损伤的临床表现及临床诊断参考依据。方法回顾性分析2000～2005年15例术后发生脊髓再灌注损伤患者的临床表现，以及在其后进行的处理方法。结果脊髓再灌注损伤患者均于术后3h以内出现自下而上的进行性运动和感觉功能障碍，即刻大剂量甲泼尼龙及神经营养药物治疗有助于挽救脊髓功能，其诊断需在排除脊髓受压的器质性因素后回顾性确诊。本组共15例患者术后出现不同程度的脊髓再灌注损伤，经对症治疗后，8例完全恢复正常，4例症状基本改善，生活可完全自理，3例症状改善不理想。结论脊髓再灌注损伤在临床上虽然少见，但后果严重，妥善的处理是改善患者生存质量的关键。

The clinical diagnosis and perioperative management of ischemic reperfusion injury to the spinal cord

Objective To summarize clinical manifestations and diagnostic criteria of ischemic reperfusion (IR) injury to the spinal cord. Method The clinical manifestations and management of 15 cases of spinal cord IR injury after operation during 2000 to 2005 were retrospectively analyzed. Result All the patients with spinal cord IR injury presented progressive ascending motor and sensory functional impairment beginning from lower extremities 3h post operation, and they were all treated immediately with methylprednisolone and neurotrophy drugs to restore spinal cord function. However, mechanical compression with organic lesion should be ruled out to establish the diagnosis of spinal cord IR injury in the retrospective analysis. Different stages of spinal cord IR injury occurred in these 15 cases. Through symptomatic treatment, 8 patients recovered completely; the clinical symptoms were basically improved in 4 cases who could lead a normal life; in 3 patients clinical symptoms were improved but not satisfactory. Conclusion Though spinal cord IR injury seldom occurs in the clinic, its damage is disastrous. Proper management is critical to save patients from poor life quality.