慢性氟中毒对大鼠大脑DNA和RNA含量的影响

研究了31只长期饲以含氟50ppm自来水而造成慢性氟中毒的Wistar大鼠大脑DNA、RNA含量的变化,以24只饲以正常饮食的大鼠作正常对照。结果显示:慢性氟中毒大鼠尿氟含量升高,出现氟斑牙,大脑组织氟含量增多,大脑重量减轻,大脑RNA含量降低、而DNA含量无明显改变。说明大脑氟量过多可抑制RNA合成,使其含量降低,并影响蛋白质合成,致大脑重量减轻。

INFLUENCE OF CHRONIC FLUOROSIS ON THE DNA, RNA CONTENTS OF BRAIN IN RATS

31 rats with chronic fluorosis produced by long-term administering excessive fluorine through the drinking water containing 50 ppm fluorine and 24 rats drinking low-fluorine water served as control are studied on the DNA, RNA contents of brain.The results showed that in the test rats as compared with the control rats, the fluorine content of urine was higher; the brains were smaller and lighter; the fluorine contents of brain were increased; the RNA contents of brain were decreased, while the DNA not changed. The findings suggest that(1) excessive fluorine in blood of the rats with chronic fluorosis can be transported through the blood-brain barrier into brain tissue,(2) excessive accumulation of fluorine in brain tissue can decrease the content and weight of brain by inhibiting RNA and protein synthesis, but can not influence the DNA content of brain.