大肠癌病人血清胃泌素水平变化的临床研究

（目的）探讨血清胃泌素与大肠癌的关系及其临床意义。（方法）用放免法测定39例行根治术的大肠癌病人空腹血清胃泌素水平。（结果）大肠癌病人血清胃泌素水平明显高于对照组（P＜0.05）；高分化腺癌组术前血清胃泌素水平显著高于对照组及中、低分化腺癌组（P＜0.05），术后其鲁沙素水平明显下降（P＜0．05）；Dukes’A、B期术前血清胃泌素水平明显高于对照组及Dukes’C期组（P＜0．05），Dukes’A期病人根治术后其胃沙素水平较术前明显下降（P＜0．05）。（结论）血清胃泌素可能对大肠癌细胞有内分泌促生长作用；血清胃泌素水平测定可作为大肠癌诊断及预后判断的辅助指标，并可为选择大肠癌病人行激素治疗提供参考依据。

Clinical Study of Serum Gastrin in Patients with Large Intestinal Carcinoma

[Purpose] To study the relationship between gastrin (G) in serum and large intestinal carcinoma(LIC) and its clin-ical significance. [Method ]G concentration in fasting serum from 39 patients with LIC after radical operation was measured by ra-dioimmunoassay. [Results] Serum G levels in patients with LIC were significantly higher than those in control groups (P<0.05),and decreased significantly after radical operation (P<0.05). Serum G levels before radical operation in highly differentiated ade-nocarcinoma were significantly higher than those of control groups and the mederate or.poor differentiation adenocarcinonu group(P<0.05), and decreased significantly after tumor resection (P<0.05). Serum G levels before radical operation in patients withDukes A,B stage were significantly higher than those in control and Dukes' C stage groups (P<0.05). Serum G levels in Dukes'A stage decreased significantly after radical operation (P<0.05). [Conclusion] G might stimulate entiocrine growth of large in-testinal carcinoma cells in vivo. Serum G level might be a adjunct index for dignosis and prognosis of LIC and provides the refer-ence proof for selections of patients with LIC to be treated with hormonotherapy.