温阳活血方对大鼠肾病模型白细胞介素4与IgE的影响

目的：探讨肾病综合征与白细胞介素-4（IL-4）及过敏反应的关系。以推断温阳活血方治疗原发性肾病综合征的可能作用机制。方法：用阿霉素（ADR）诱导一种类似人类微小病变肾病模型。选用温阳活血方进行治疗。并设空白。病理及强的松对照组，观测尿蛋白，血清IL-4和IgE等含量的变化。结果：造模组IL-4高于正常组，温阳活血方及强的松均有降低血清IL-4的作用，且IL-4与同期尿蛋白呈直线正相关。IgE改变无统计学差异。结论：温阳活血方减轻肾病模型尿蛋白的作用可能与降低血清IL-4水平有关。

The Effect of Waring Yang to Promote Blood Circulation-WYRT on the Levefs of IL-4 and IgE in Nephrotic Rat Iuduced by Adriamycin Adriamycin-Induced Nephrotic Syndrome

Objective:To investigate the potential mechanisms of treating with WYPT on idiopathic nephrotic rat.Methods:A minimal change nephropathy model similar to humans was induced by adriamycin (ADR) in rat. The rats were randomly divided into four groups:normal contral, nephrotic control, the groups treated with WYPT, Prednisone. The teinurine, serum IL-4 and immunoglobulin E (IgE) were measured.Results:The concentration of serm IL-4 of nephrotic control gromp was higher than that of normal control group. There was a considerable decrease serum IL-4 in the group treated with WYPT or prednisone. The change of serum IgE did not have meaning on statistics. Conclusion:The decreasing IL-4 may be one of the mechanisms of WYPT decreasing proteinuria.