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| 星形细胞瘤PTEN、p27的表达及相关性研究 | |
| 引用本文： | 郭艳琳,常冰梅,徐菁,乔建新. 星形细胞瘤PTEN、p27的表达及相关性研究[J]. 山西医科大学学报, 2006, 37(5): 472-473 |
| 作者姓名： | 郭艳琳 常冰梅 徐菁 乔建新 |
| 作者单位： | 1. 山西医科大学病理学教研室,太原,030001 2. 山西医科大学生物化学与分子生物学教研室 3. 山西省人民医院急诊科 |
| 摘 要： | 目的检测PTEN和p27在星形细胞瘤中的表达,探讨二者表达的意义。方法采用免疫组化S-P法检测星形细胞瘤PTEN和p27的表达,应用SPSS10.0统计软件进行数据处理。结果PTEN、p27在星形细胞瘤表达阳性率均随病理分级升高而降低(P<0.05);PTEN表达水平与p27表达水平正相关(P<0.05)。结论PTEN及p27表达下调与星形细胞瘤的发生发展有关。PTEN可能通过正调节p27的表达发挥其抑癌作用。 |
| 关 键 词： | 基因,PTEN 基因,p27 星形细胞瘤 |
| 文章编号： | 1007-6611（2006）05-0472-02 |
| 收稿时间： | 2006-05-15 |
| 修稿时间： | 2006-05-15 |
PTEN and p27 expression and relationship between both in astrocytoma |
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| GUO Yan-lin, CHANG Bing-mei, XU Jing, et al. PTEN and p27 expression and relationship between both in astrocytoma[J]. Journal of Shanxi Medical University, 2006, 37(5): 472-473 | |
| Authors: | GUO Yan-lin CHANG Bing-mei XU Jing et al |
| Affiliation: | Dept of Pathology, Shanxi Medical University, Taiyuan 030001, China |
| Abstract: | Objective To examine the expression of PTEN and p27 in astrocytoma and to investigate their meaning. Methods Expressions of them were determined by immuohistochemistry S-P technique.Data were processed by SPSS Version 10.0.Results The positive rates of PTEN and p27 protein expression were decreased with histopathological grading(P<0.05);p27 showed a positive correlation with PTEN expression level(P<0.05).Conclusion PTEN and p27 expression has descending trends in astrocytoma,indicating that both genes may play an important role in the carcinogenesis and development of astrocytoma.PTEN may suppress the tumor through up-regulating p27 expression. |
| Keywords: | genes PTEN genes p27 astrocytoma |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |