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Guillain-Barré syndrome in South-West Stockholm, 1973–1991, 3. Clinicoepidemiological subgroups
Authors:J. de  Pedro-Cuesta   V. Abraira  G.-X. Jiang  G. Solders  S. Fredrikson
Affiliation:Department of Applied Epidemiology, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain;Division of Neurology, Department of Clinical Neuroscience and Family Medicine, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden;Biostatistics Unit "Ramon y Cajal" Hospital, Madrid, Spain;Department of Clinical Neurophysiology, Huddinge University Hospital, Stockholm, Sweden
Abstract:Using hierarchical cluster analysis, applied to 47 cases of Guillain-Barre Syndrome (GBS) incident in South-West Stockholm (SWS) during the period from January 1973 to June 1992, we identified three major clinicoepidemiological subgroups. The first subgroup, 25.5% of the cases (26.7 ± 6.7 years), recorded a peak incidence at ages 20–29 years and presented significant differences from other subgroups, a high proportion of cases with onset at low age preceded by respiratory infection (83.3%) and with normal motor conduction velocity (50.0%). Also found, were less affected biological parameters, a rapidly progressive course and independence in gait at one month after onset. A second subgroup, 27.7% of cases, was severely affected, clinically and functionally. It consisted predominantly of young individuals (22.7 ± 11.1 years), with a high incidence (69.2% of cases) in autumn. A third subgroup, comprising 40.47; of cases, was older (61.1 ± 11.0 years) and, in general, also severely affected. The incidence of this form appeared to be invariant with time.
Keywords:acute inflammatory demyelinating polyneuropathy (AIDP)    classification    cluster    epidemiology    etiology    Guillain-Barre syndrome    incidence    methods    surveillance
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