Rosai-Dorfman disease of the gastrointestinal tract: report of a case and review of the literature |
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Authors: | Alatassi Houda Ray Mukunda B Galandiuk Susan Sahoo Sunati |
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Institution: | Department of Pathology, University of Louisville Hospital, Louisville, KY 40202, USA. |
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Abstract: | Rosai-Dorfman disease (RDD) is a rare, acquired disease of unknown etiology that affects primarily children and young adults. It is characterized by a proliferation of distinctive histiocytes in the lymph nodes and/or extranodal sites. Involvement of the gastrointestinal tract is rare. We report a case of RDD in a 60-year-old woman who presented with hematochezia and was found to have RDD of the rectum presenting as a rectal mass. This report highlights the current pathogenetic mechanisms, immunohistochemical markers, and the gastrointestinal manifestations of RDD. |
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