Influence of neurons of the parafascicular region on neuronal transmission from perforant pathway through dentate gyrus |
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| Authors: | Dennis Dahl Jonathan Winson |
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| Affiliation: | 1. Key Lab. of Civil Engineering Safety and Durability of China Education Ministry, Dept. of Civil Engineering, Tsinghua University, Beijing 100084, China;2. Beijing Engineering Research Center of Steel and Concrete Composite Structures, Dept. of Civil Engineering, Tsinghua University, Beijing 100084, China;1. Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People’s Republic of China;2. Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA 30302, United States;1. State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China;2. Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China |
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| Abstract: | We have previously reported that activation of an ascending brainstem pathway by stimulation of the median raphe nucleus (MR) influences neuronal transmission from the perforant pathway through the dentate gyrus in a behaviorally dependent manner. In particular, stimulation of the MR markedly facilitated such transmission when applied during slow-wave sleep (SWS), but was ineffective when applied during the still-alert state (SAL). We present here evidence for a relay in this circuit located rostral to the MR in cells proximal to the fasciculus retroflexus (PF, parafascicular region). In contrast to stimulation of the MR, stimulation of the PF facilitates neuronal transmission from the perforant pathway through the dentate gyrus during both SWS and SAL indicating the presence of a gate at or proximal to the PF that is preferentially closed during SAL. |
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| Keywords: | dentate gyrus neuronal transmission brainstem influence |
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