降纤酶治疗脑梗死76例临床疗效观察

目的 :观察降纤酶对脑梗死的治疗效果及副作用。方法 :选择脑梗死患者 76例 ,应用降纤酶 ,首剂 10u ,第 2、3日各 5u连续静滴 3天 ,然后隔日 5u再用 2次 ,总量 30u ,并与 5 %低分子右旋糖酐 +维脑路通静滴 7～ 10d的 34例脑梗死患者作对照研究 ,两组其余用药大致相同。治疗前后作神经功能评估 ,观察疗效及血纤维蛋白原、红细胞压积变化。结果 :降纤酶治疗组与对照组比较 ,治疗后具有明显降低血纤维蛋白原、降低红细胞压积的作用 ,具有显著差异 (P <0 0 1)。治疗终神经功能缺损程度评分 ,日常生活能力评定均有显著差异 (P <0 0 1)。对血小板、出凝血时间无明显影响。结论 :降纤酶治疗脑梗死能促进神经功能的早期恢复 ,降低致残率 ,安全性高

Clinical effect observation of defibrasum 76 cases of brain infarction

Objective:To investigate the therapy effect and side effect of defibrasum.Methods:76 cases brain infarction patients took defibrasum,initial dose 10 u,5 uin the second and third day,venoclysis continually three days,5 u twice qod,total 30 u,compared with 34 cases brain infarction patients venoclysising 5% low molecular dextran and venoruton 7 to 10 days,other treatment was similar.Assess nerve function,observe effect,fibrinogen,hematocrit before and after treatment.Results:Compared with the control group,defibrasum decreased fibrinogen and hematocrit significantly (P<0 01).There were significant difference in nerve function injury extent and regular life ability assessment after treatment(P<0 01).There were no significant effect on platelet,bleeding time,coagulation time.Conclusion:Defibrasum can accelerate nerve function early convalescence,decrease disablity and increase safety.