| 猪不同部位皮肤与人体皮肤对药物渗透性的比较 |
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| 引用本文： | 黄小平,万新祥,王卓斌,何尚宽,励石寒.猪不同部位皮肤与人体皮肤对药物渗透性的比较[J].第一军医大学分校学报,1997(1). |
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| 作者姓名： | 黄小平 万新祥 王卓斌 何尚宽 励石寒 |
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| 作者单位： | 解放军广州医学高等专科学校药剂学教研室 广州510315(黄小平，万新祥，王卓斌)，解放军广州医学高等专科学校解剖学教研室 广州510315(何尚宽)，解放军第177中心医院 广州510317(励石寒) |
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| 摘 要： | 以苯甲酸、水杨酸、甲硝唑为模型药物,对猪耳和猪腹部皮肤进行体外药物渗透实验,在相同条件下与正常人体皮肤进行了渗透性差别的比较研究。结果表明:猪耳和猪腹部皮肤与人体皮肤对药物渗透性具有相似性,特别是猪耳皮肤对药物体外透皮实验是个有价值的动物模型。
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| 关 键 词： | 透皮吸收 猪耳皮肤 猪腹皮肤 人皮肤 |
Comparison of pig skins of different position with human skin in skin permeability of drugs |
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| Huang Xiaoping,Wan Ximdang,Wang Zhuobin.et at..Comparison of pig skins of different position with human skin in skin permeability of drugs[J].Journal of Branch Campus of the First Military Medical University,1997(1). |
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| Authors: | Huang Xiaoping Wan Ximdang Wang Zhuobinet at |
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| Abstract: | benzoic acid, acetglsalicylic acid and metronidazole as model drugs and pig ear and pig abdominal skins for experimental material, the experiment in-vitro skin permeability of drugs was undertaken. In the same conditions the animal skins were compared with human skin in the rate and amount of the drug permeability through the skins. The results showed that pig ear and pig abdominal skins had similarity in drug permeability, and with hunman skin especially, pig ear skin was a valuable animal model for in -vitro drug permeability. |
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| Keywords: | percutanous permeability pig ear skin pig abdominal skin human skin |
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