复方决明子胶囊亚急性毒性研究

目的了解复方决明子胶囊的毒性。方法根据30 d喂养试验方法将大鼠分为阴性对照组及低、中、高3个剂量组。连续喂养30 d后,摘眼球采血作血常规及生化指标测定,取出肝、肾、脾、睾丸称重,并对肝、肾、脾、胃肠、睾丸、卵巢作组织病理学检查。结果各剂量组大鼠的体重及其增重、进食量、食物利用率与阴性对照组比较差异均无显著性(P>0.05);血红蛋白含量、红细胞计数、白细胞计数及白细胞分类均在正常值范围内;血清谷丙转氨酶、谷草转氨酶、尿素氮、肌酐、总胆固醇、甘油三酯、血糖、总蛋白、白蛋白测定值均在正常值范围内。大鼠的脏体比与阴性对照组比较,差异无显著性(P>0.05)。结论大鼠服用复方决明子胶囊30 d,对机体未见不良影响。

Study on Subacute Toxicity of Compound Pine Torch Capsule

Objective To understand the subacute toxicity of compound pine torch capsule. Methods According to the 30-day feeding method,we categorized the rats into the control group,the low-dosage group,the medium-dosage group and the high-dosage group.After 30 days feeding,the eyeball pick-up blood samples were performed blood routine and blood biochemical analysis;the liver,kidney,spleen,and testicles specimens were weighed and performed pathology examination of liver,spleen,intestines and stomach,testicles,and ovary tissues.Results Compared with the control group,the original body weight,the increased body weight and the food utilization ratio of the other three groups were similar(P>0.05).Hemoglobin content,red blood corpuscles and leukocyte counts,and leukocyte differential count were within the normal range.The serum glutamate pyruvate transaminase(SGPT),glutamine-oxaloacetic transaminase(GOT),urea nitrogen,creatinine,cholesterol,triglyceride,blood sugar,total albumen and albumin levels were within the range of the normal standard.The rats have no significant difference with the control group(P>0.05). Conclusion Rats did not show any harmful effects after taking compound pine torch capsule 30 days.