东北红豆杉化学成分的分离与鉴定

目的对东北红豆杉(Taxus cuspidtaSibe.et Zucc.)的化学成分进行研究。方法采用硅胶柱色谱等方法进行分离纯化,根据理化性质和NMR波谱数据进行结构鉴定。结果分离得到8个化合物,分别鉴定为大黄素甲醚(physcion,1)、油酸甲酯(methyl oleate,2)、紫杉宁(taxinine,3)、5α-羟基-9α,10β,13α-三乙酰氧紫杉烷-4(20),11-二烯(5α-hydroxy-9α,10β,13α-triacetoxytaxa-4(20),11-diene,4)、云南紫杉宁C(taxuyunnanine C,5)、2-去乙酰氧-5α-羟基紫杉宁J(2-deacetoxydecin-namoyl taxinine J,6)、2-去乙酰氧紫杉宁J(2-deacetoxytaxinine J,7)、11-羟基-12-甲氧基松香烷-8,11,13-三烯-3,7-二酮(11-hydroxy-12-methoxyabieta-8,11,13-triene-3,7-dione,8)。结论化合物1、2为首次从红豆杉属植物中分离得到,化合物4、8为首次从该种植物中分离得到。

Isolation and identification of chemical constituents from Taxus cuspidta Sibe. et Zucc.

Objective To isolate the chemical constituents from Taxus cuspidta Sibe. et Zucc. and elucidate their structures. Method The compounds were isolated by chromatography on silica gel column and identified based on their physico-chemical properties and spectral analysis. Result Eight compounds were obtained and elucidated as: physcion (1), methyl oleate (2), taxinine (3), 5α-hydroxy- 9α,10β,13α-triacetoxytaxa-4(20),11-diene (4), taxuyunnanine C (5), 2-deacetoxydecinnamoyl taxinine J (6), 2-deacetoxytaxinine J (7), 11-hydroxy-12-methoxyabieta-8,11,13-triene-3,7-dione (8), respectively. Conclusion Compounds 1 and 2 are obtained from the Taxus genus for the first time, while compounds 4 and 8 are isolated from this plant for the first time.