| 瓜蒌皮提取物对大鼠主动脉PDC Ca2+内流的影响 |
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| 引用本文： | 莫尚武,刘宁,张坐奎,吴玉蓉,杨涛四.瓜蒌皮提取物对大鼠主动脉PDC Ca2+内流的影响[J].中草药,1999,30(9):674-676. |
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| 作者姓名： | 莫尚武 刘宁 张坐奎 吴玉蓉 杨涛四 |
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| 作者单位： | ：莫尚武* |
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| 基金项目： | 国家自然科学基金19775034;核工业科学基金 |
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| 摘 要： | 为了研究瓜蒌皮治疗冠心病的有效成分,用醚醇法和水煎醇沉法提取瓜蒌皮的有效成分,并用45Ca跨膜测量方法研究各提取物对大鼠主动脉PDC钙通道Ca2+内流的影响。发现氯仿和醇溶物能阻滞Ca2+内流,水溶物具有相反的作用,其中氯仿提取物浓度为30 mg/mL时,使Ca2+内流量比对照下降31.57%。实验结果表明瓜蒌皮中可能有7种组分具有治疗冠心病的活性。
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| 关 键 词： | 瓜蒌皮 钙拮抗剂 放射性同位素(45)~Ca 冠心病 |
| 收稿时间： | 1998/1/12 0:00:00 |
| 修稿时间： | 1998-01-12 |
Influence of Extract of Mesocarp of Mongolian Snakegourd (Trichosanthes kirilowii) on Transmembrane Ca2+ Influx in Rat Aortic Ring |
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| Mo Shangwu,Liu Ning,Wu Yurong.Influence of Extract of Mesocarp of Mongolian Snakegourd (Trichosanthes kirilowii) on Transmembrane Ca2+ Influx in Rat Aortic Ring[J].Chinese Traditional and Herbal Drugs,1999,30(9):674-676. |
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| Authors: | Mo Shangwu Liu Ning Wu Yurong |
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| Institution: | Institute of Nuclear Sciences, Technology, Sichuan University, Chengdu 610064;Institute of Nuclear Sciences, Technology, Sichuan University, Chengdu 610064;Institute of Nuclear Sciences, Technology, Sichuan University, Chengdu 610064 |
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| Abstract: | Powdered mesocarp of Trichosanthes kirilowii Maxim. was extracted with petroleum ether, ethanol and water, partitioned with chloroform and ethyl acetate or precipitated with the addition of ethanol to obtain a total of 14 fractions. Their effects on Ca2+ influx of rat aortic rings were studied with 45Ca transmembrane influx technique. Results showed that 7 fractions could block potential dependent Ca2+ influx, suggesting their potential use for the treatment of coronary heart diseases. Among them, chloroform extract resulted in a decrease of Ca2+ influx of 31.57% in comparison with the control. |
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