胃癌组织中骨形成蛋白4的表达

目的:研究骨形成蛋白4(bone morphogenetic protein-4,BMP-4)在胃癌中的表达及其与临床病理参数间的关系.方法:以免疫组织化学法(SP法)检测90例胃癌及30例癌旁组织胃黏膜石蜡切片中BMP-4的表达,并分析其与临床病理参数的关系.结果:胃癌组织中BMP-4阳性表达率23.3％(21/90),癌旁组织胃黏膜阳性表达率为3.3％(1/30),两组间比较差异有统计学意义(χ2=6.011,P=0.014).此外,胃癌组织中BMP-4蛋白的阳性表达在不同性别、年龄(≥60岁或<60岁)及肿瘤大小(≥5 cm或<5 cm)的患者中无统计学差异;胃窦部的肿瘤及肿瘤浸润深、分化程度差及有淋巴结转移的胃癌患者BMP-4阳性表达率分别明显高于其他部位肿瘤及肿瘤浸润浅、分化程度高及无淋巴结转移者(P<0.05).结论:胃癌组织中存在BMP-4的阳性表达,其表达与胃癌的恶性程度有关.

Expression of bone morphogenetic proteins-4 in human gastric cancer

Objective:To determine the expression level of bone morphogenetic proteins-4 (BMP-4) and the relationship between the expression of BMP-4 and the clinical/pathological parameters in patients with gastric cancer. Methods:Using im-munohistochemical staining technique ,expressions of BMP-4 were investigated in different tissues from 90 gastric cancer specimens and 30 specimens from normal gastric mucosa as control. ResultS:The positive rate of BMP-4 was 23. 3% (21/90) in gastric cancer and 3. 3% (1/30) in normal gastric mucosa. The expression of BMP-4 in gastric cancer was closely related with locus, serosa infiltration,cell differentiation and lymph node metastasis (P<0. 05). Conclusion: BMP-4 protein is over-expressed in gastric cancer,and might be related to the formation of gastric cancer,heterotopic ossification and bone metastasis.