| HPLC法测定盐酸倍他司汀氯化钠注射液的含量 |
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| 引用本文： | 郭宇鹏,王克柳,夏方亮.HPLC法测定盐酸倍他司汀氯化钠注射液的含量[J].齐鲁药事,2005,24(8):469-470. |
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| 作者姓名： | 郭宇鹏 王克柳 夏方亮 |
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| 作者单位： | 1. 滨州市药检所,滨州,256618
2. 山东鲁北药业有限公司,沾化,256680 |
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| 摘 要： | 目的建立HPLC法测定盐酸倍他司汀氯化钠注射液中盐酸倍他司汀的含量。方法用C18柱为固定相,以pH4·5磷酸三乙胺缓冲液为流动相,检测波长为261nm。结果盐酸倍他司汀在20~100μg·ml-1浓度范围内呈良好的线性关系(r=0·9999),其平均回收率为100·2%,RSD为1·04%(n=5)。结论此方法简便、快速、准确。
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| 关 键 词： | HPLC 盐酸倍他司汀氯化钠注射液 盐酸倍他司汀 含量测定 |
| 文章编号： | 1672-7738(2005)08-0469-02 |
Determination of Betahistine Hydrochloride and Soudium Chloride Injection by HPLC |
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| GUO Yu-Peng,Wang Ke-liu,Xia Fang-liang.Determination of Betahistine Hydrochloride and Soudium Chloride Injection by HPLC[J].qilu pharmaceutical affairs,2005,24(8):469-470. |
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| Authors: | GUO Yu-Peng Wang Ke-liu Xia Fang-liang |
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| Institution: | Guo Yu-peng,Wang Ke-liu~1,Xia Fang-liang |
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| Abstract: | Objective To establish a HPLC method for determination of Betahistine hydrochloride in Soudium Chloride Injection.Methods C18 column was used.The mobile phase was the mixture of buffer solution of phosphoric acid-triethylamine(pH4.5).The detective wavelength was at 261nm.Results The linear range of Betahistine Hydrochloride was in 20～100μg·ml~-1(r=0.9999,n=5),the average recovery was 100.2% and RSD was 1.04% respectively.Conclusion This method was simple,rapid and accurate. |
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| Keywords: | HPLC Betahistine Hydrochloride and Soudium Chloride Injection Betahistine Hydrochloride determination |
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