| 胃内滞留释药系统的研究新进展 |
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| 引用本文： | 施祥杰,周建平. 胃内滞留释药系统的研究新进展[J]. 药学进展, 2010, 34(2): 55-60. DOI: 10.3969/j.issn.1001-5094.2010.02.002 |
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| 作者姓名： | 施祥杰 周建平 |
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| 作者单位： | 中国药科大学药剂学教研室,江苏,南京,210009 |
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| 摘 要： | 介绍近年来胃内滞留释药系统的研究进展。胃内滞留释药系统可增加以胃肠道上部吸收为主的药物的吸收,延长药物作用时间,提高药物生物利用度。目前胃内滞留释药系统主要有5种类型：胃内漂浮型、胃内黏附型、胃内膨胀型、胃底沉降型和磁性胃内滞留型。
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| 关 键 词： | 胃内滞留 缓释 给药系统 |
Current Advances in Gastro-retentive Drug Delivery System |
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| SHI Xiang-jie,ZHOU Jian-ping. Current Advances in Gastro-retentive Drug Delivery System[J]. Progress in Pharmaceutical Sciences, 2010, 34(2): 55-60. DOI: 10.3969/j.issn.1001-5094.2010.02.002 |
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| Authors: | SHI Xiang-jie ZHOU Jian-ping |
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| Affiliation: | SHI Xiang-jie,ZHOU Jian-ping(Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | The recent advances in research on the gastro-retentive drug delivery systems were reviewed.Gastro-retentive drug delivery system can prolong gastric residence time,resulting in increasing absorption and bioavailability of the drug.Gastro-retentive drug delivery system can be divided into five forms:floating systems,mucoadhesive systems,expandable systems,high-density systems and magnetic systems. |
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| Keywords: | gastro-retentive sustained release drug delivery system |
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