壮族地区城市妇女宫颈细胞DNA定量分析机会性筛查宫颈病变临床研究

目的:探讨DNA倍体分析检测方法对宫颈早期病变筛查的临床应用价值.方法:将1200例妇科门诊患者进行宫颈细胞取样,分别采用液基薄层细胞和DNA倍体分析系统进行宫颈早期病变筛查,对筛查阳性病例进行阴道镜下活检,并对两组阳性结果进行比较分析.结果:DNA倍体分析组筛查阳性率29.33％,TCT阳性率8.17％,两者比较有极显著性差异(P＜0.01),两者联合对宫颈病变诊断率达88.87％.结论:DNA倍体分析检测方法对宫颈病变较液基薄层细胞更具敏感性.

Clinical research of cervical cell DNA quantitative analysis in opportunistic screening of cervical diseases among women in cities of Zhuang national minority regions

Objective:To investigate the clinical application of DNA analysis and detection methods of autotetraploid to screening of early stage of cervical diseases.Methods:Cervical cells of 1,200 gynecological outpatients were sampled.Thinprep cytologic test(TCT) and DNA autotetraploid analysis system were applied respectively to screening cervical diseases of the early stage.The positive cases were conducted vaginal microscopically biopsy and the positive outcome of patients in both group was compared and analyzed.Results:The positive rate detected by TCT and DNA autotetraploid analysis system was 8.17% and 29.33% respectively,which was of significant difference in comparision(P<0.01).And the diagnostic rate for cervical diseases reached 88.87% by combining the two methods.Conclusion:DNA autotetraploid analysis system is more sensitive to cervical diseases than TCT.