岩鹿乳康胶囊对乳腺增生大鼠血清雌孕激素的影响

目的:探讨岩鹿乳康胶囊对成年雌性乳腺增生大鼠血清雌激素、孕激素水平的影响。方法:选取Wister大鼠60只,将其随机分为6组:空白组、疾病模型组、去卵巢组、三苯氧胺组、乳癖消组、岩鹿乳康胶囊组。采用酶联免疫吸附试验(ELISA)检测大鼠血清中雌二醇(E_2)和孕酮(P)水平。结果:与乳癖消组以及疾病模型组比较,岩鹿乳康组血液中E_2的水平均显著降低(P0.05),P水平明显升高(P0.05);与三苯氧胺组比较,岩鹿乳康组血液中E_2和P水平差异无统计学意义(P0.05)。结论:岩鹿乳康胶囊能显著降低血中雌激素以及升高孕激素水平。

Effects of Yanlu Rukang Capsule on Estrogen and Progesterone in Serum of Rats with Hyperplasia of Mammary Glands

To study the effects of Yanlu Rukang Capsule on estrogen and progesterone in serum of rats with hyperplasia of mammary glands. Methods:All 60 Wister rats were randomly divided into six groups: blank control group, tamoxifen group, Yanlu Rukang group, Rupixiao group, disease model group, ovariectomized group. Then, the content of estradiol (E2) and progesterone (P) in serum of rats were detected by ELISA methods. Results:Compared with Rupixiao group and model group, the content of E2 in blood in the Yanlu Rukang group was significantly decreased, and the content of P was significantly higher (P<0.01); Compared with tamoxifen group, the content of E2 and P in the blood in the Yanlu Rukang group did not significantly changed, and there was no statistical significance (P>0.05). Conclusion:Yanlu Rukang capsule can significantly reduce estrogen and elevated progesterone levels in blood.