| 蒺藜化学成分分析及其皂苷类成分对心血管疾病作用的实验研究进展 |
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| 引用本文： | 赵外荣,施雯婷,郁丘婷,胡春蕊,金佳虹,周忠焱,陈昕琳.蒺藜化学成分分析及其皂苷类成分对心血管疾病作用的实验研究进展[J].上海中医药大学学报,2018,32(4):105-108. |
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| 作者姓名： | 赵外荣 施雯婷 郁丘婷 胡春蕊 金佳虹 周忠焱 陈昕琳 |
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| 作者单位： | 上海中医药大学附属龙华医院 |
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| 基金项目： | 上海市科委科研计划项目(16ZR1437600)；上海申康医院发展中心慢性病综合防治项目(SHDC12015313)；中医药文化背景下的医养结合示范工程建设项目(A1-U1720501030101);国家自然科学基金青年基金资助项目(81603549) |
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| 摘 要： | 通过梳理国内外文献,概述中药蒺藜的化学成分,并就其皂苷类成分对心血管疾病的作用及机制进行总结分析。蒺藜的化学成分主要包括皂苷类、黄酮类、生物碱等,其中皂苷类为主要活性成分。现代药理研究发现,蒺藜皂苷类成分对心血管疾病疗效显著,具有抗心肌缺血、抗动脉粥样硬化、改善心功能、降压、降脂等多重效应,其机制可能与保护心肌细胞、减轻炎症损伤、改善内皮功能、抑制血管平滑肌增殖,抗血小板聚集等有关。
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| 关 键 词： | 蒺藜 化学成分 皂苷 心血管疾病 综述 |
Experimental research progress on chemical component of Tribuli Fructus and effects of its saponins on cardiovascular diseases |
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| ZHAO Wairong,SHI Wenting,YU Qiuting,HU Chunrui,JIN Jiahong,ZHOU Zhongyan and CHEN Xinlin.Experimental research progress on chemical component of Tribuli Fructus and effects of its saponins on cardiovascular diseases[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2018,32(4):105-108. |
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| Authors: | ZHAO Wairong SHI Wenting YU Qiuting HU Chunrui JIN Jiahong ZHOU Zhongyan and CHEN Xinlin |
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| Institution: | Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China and Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China |
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| Abstract: | By sorting out the domestic and foreign literatures, the chemical constituents of Tribuli Fructus are summarized, and the effects and mechanisms of its saponins on cardiovascular diseases are summarized and analyzed. The chemical constituents of Tribuli Fructus mainly include saponins, flavonoids and alkaloids, among which saponins are the main active components.Modern pharmacological studies have found that the saponins in Tribuli Fructus show significant efficacy in treating cardiovascular diseases, with multi effects such as anti-myocardial ischemia, anti-atherosclerosis, improving heart function, reducing blood pressure and lowering blood lipid. The mechanism may be related to the protection of myocardial cells, reduction of inflammatory injury, improvement of endothelial function, inhibition on proliferation of vascular smooth muscle cells and anti-platelet aggregation. |
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