| 还原汤治疗急性脑梗死的疗效及对血清炎症因子的影响 |
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| 引用本文： | 张瑞,张宗奇,赵稼萤,黄雪元,黄庆松,万浩鹏.还原汤治疗急性脑梗死的疗效及对血清炎症因子的影响[J].上海中医药大学学报,2018,32(3):28-32. |
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| 作者姓名： | 张瑞 张宗奇 赵稼萤 黄雪元 黄庆松 万浩鹏 |
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| 作者单位： | 上海市嘉定区中医医院内科;上海中医药大学附属曙光医院脑病科 |
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| 基金项目： | 上海市嘉定区中医重点学科项目(2017-ZYZDZK-02)；上海市嘉定区中医医院院级科研项目(2015-08) [ |
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| 摘 要： | 目的:评价还原汤治疗急性脑梗死的临床疗效及其对患者血清炎症因子IL-6、TNF-α和hs-CRP水平的影响。方法:将符合标准的100例急性脑梗死患者随机分为治疗组和对照组,每组各50例。两组患者均给予西医常规治疗,治疗组在常规治疗基础上加用还原汤口服,治疗周期为15 d。比较两组患者的临床疗效;治疗前后及发病90 d随访时,采用美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分评价患者的神经功能缺损程度,采用Barthel指数(Barthel index,BI)和改良Rankin量表(modified Rankin scale,mRS)评分评定患者的生活质量;治疗前后检测两组患者的IL-6、TNF-α和hs-CRP水平。结果:治疗后,治疗组和对照组的临床总有效率分别为83.7%和55.3%,治疗组的疗效优于对照组(P0.01)。与治疗前比较,治疗后及随访时,治疗组患者的NIHSS、mRS评分显著降低(P0.01),BI评分显著升高(P0.01),对照组患者的NIHSS评分亦显著降低(P0.01),且随访时,对照组患者的mRS评分显著降低(P0.01)、BI评分显著升高(P0.01)。与治疗后比较,随访时,两组患者的NIHSS评分均降低(P0.05),且治疗组患者的BI评分明显升高(P0.05)、mRS评分显著降低(P0.05)。与对照组比较,治疗后及随访时,治疗组患者的NIHSS、mRS评分均显著降低(P0.01,P0.05),BI评分显著升高(P0.01,P0.05)。治疗后,两组患者的IL-6、TNF-α、hs-CRP水平较治疗前均明显下降(P0.01),且治疗组患者的IL-6、TNF-α、hs-CRP水平低于对照组(P0.05,P0.01)。结论:还原汤结合西医常规疗法治疗急性脑梗死,能够有效改善患者的临床症状和体征,提高其生活质量及远期疗效,并能降低患者的血清炎症因子水平。
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| 关 键 词： | 还原汤 急性脑梗死 中西医结合疗法 炎症因子 |
Efficacy of Huanyuan Decoction in the treatment of acute cerebral infarction and effects on serum inflammatory cytokines |
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| ZHANG Rui,ZHANG Zongqi,ZHAO Jiaying,HUANG Xueyuan,HUANG Qingsong and WAN Haopeng.Efficacy of Huanyuan Decoction in the treatment of acute cerebral infarction and effects on serum inflammatory cytokines[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2018,32(3):28-32. |
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| Authors: | ZHANG Rui ZHANG Zongqi ZHAO Jiaying HUANG Xueyuan HUANG Qingsong and WAN Haopeng |
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| Institution: | Department of Internal Medicine,Shanghai Jiading Hospital of Traditional Chinese Medicine,Shanghai 201800,China,Department of Encephalopathy,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China,Department of Internal Medicine,Shanghai Jiading Hospital of Traditional Chinese Medicine,Shanghai 201800,China,Department of Internal Medicine,Shanghai Jiading Hospital of Traditional Chinese Medicine,Shanghai 201800,China,Department of Internal Medicine,Shanghai Jiading Hospital of Traditional Chinese Medicine,Shanghai 201800,China and Department of Internal Medicine,Shanghai Jiading Hospital of Traditional Chinese Medicine,Shanghai 201800,China |
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| Abstract: | |
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| Keywords: | Huanyuan Decoction acute cerebral infarction therapy of integrated traditional Chinese and western medicine inflammatory cytokines |
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