| 七叶灵方联合西医常规疗法治疗放射性肺炎的临床观察 |
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| 引用本文： | 郭毅峻,崔清,刘俊,李洪选,顾嘉钦,张铭,董昀.七叶灵方联合西医常规疗法治疗放射性肺炎的临床观察[J].上海中医药杂志,2018,52(8):33-36. |
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| 作者姓名： | 郭毅峻 崔清 刘俊 李洪选 顾嘉钦 张铭 董昀 |
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| 作者单位： | 上海交通大学附属胸科医院中西医结合科;上海交通大学附属胸科医院放疗科;上海交通大学附属胸科医院药剂科 |
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| 基金项目： | 上海市科委中医引导项目(15401933400)；上海市卫计委中医药临床能力平台建设类项目(ZY3-LCPT-2-1001) |
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| 摘 要： | 目的观察七叶灵方联合西医常规疗法治疗放射性肺炎的临床疗效。方法将80例放射性肺炎患者随机分为对照组和观察组,每组40例。对照组予西医常规治疗,观察组在对照组基础上加服七叶灵方。两组疗程均为2个月,观察临床疗效,比较中医证候积分、癌症治疗功能评价系统(FACT-G)评分、血清相关细胞因子(TGF-β1、TNF-α、IL-6)水平及肺功能的变化情况。结果 (1)观察组、对照组总有效率分别为80.0%、67.5%;组间临床疗效比较,观察组优于对照组(P0.05)。(2)治疗前后组内比较,观察组咳嗽、咯痰、腰酸腿软、头晕耳鸣积分较治疗前降低(P0.05);对照组咳嗽、咯痰积分较治疗前降低(P0.05);组间治疗后比较,观察组中医证候改善情况优于对照组(P0.05)。(3)治疗前后组内比较,两组FEV1/FVC%、FEV1%均较治疗前升高(P0.05),同时观察组FVC较治疗前升高(P0.05);组间治疗后比较,观察组FVC、FEV1/FVC%、FEV1%均高于对照组(P0.05)。(4)治疗前后组内比较,仅观察组在生理状况、功能状况评分及FACT-G量表总分方面较治疗前升高(P0.05);组间治疗后比较,观察组生理状况、社交/家庭状况、功能状况评分及量表总分高于对照组(P0.05)。(5)治疗前后组内比较,仅观察组血清TGF-β1、TNF-α、IL-6水平较治疗前下降(P0.05);组间治疗后比较,观察组血清TGF-β1、TNF-α、IL-6水平低于对照组(P0.05)。结论七叶灵方联合西医常规疗法治疗放射性肺炎疗效满意,可明显改善患者的临床症状及肺功能,控制炎症反应,提高生存质量。
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| 关 键 词： | 放射性肺炎 七叶灵方 肺功能 生存质量 细胞因子 |
| 收稿时间： | 2018/5/4 0:00:00 |
Clinical observation of Qiyeling Decoction combined with routine western medicine therapy in treating radiation pneumonitis |
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| GUO Yijun,CUI Qing,LIU Jun,LI Hongxuan,GU Jiaqin,ZHANG Ming and DONG Yun.Clinical observation of Qiyeling Decoction combined with routine western medicine therapy in treating radiation pneumonitis[J].Shanghai Journal of Traditional Chinese Medicine,2018,52(8):33-36. |
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| Authors: | GUO Yijun CUI Qing LIU Jun LI Hongxuan GU Jiaqin ZHANG Ming and DONG Yun |
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| Institution: | Department of Integrated Chinese and Western Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China,Department of Integrated Chinese and Western Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China,Department of Radiotherapy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China,Department of Radiotherapy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China,Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.,Department of Integrated Chinese and Western Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China and Department of Integrated Chinese and Western Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China |
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| Abstract: | |
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| Keywords: | radiation pneumonitis Qiyeling Decoction pulmonary function quality of life cytokines |
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