滋阴平肝法对子痫前期孕妇血脂水平及妊娠结局的影响

目的:探讨滋阴平肝法对子痫前期(PE)孕妇血脂水平及妊娠结局的影响。方法:选取2014年1月至2017年12月应城市人民医院收治的收治的PE孕妇140例随机分为观察组和对照组,每组70例。2组均采用西医常规治疗,观察组在此基础上采用滋阴平肝法进行治疗,2组均连续治疗直至分娩或终止妊娠。比较2组治疗前后中医证候积分、血脂水平与相关指标;统计2组孕妇临床疗效及母婴妊娠结局。结果:与治疗前比较,治疗后2组头痛、眩晕、腹部疼痛等中医证候积分均显著下降,且观察组低于对照组(P0.01);与治疗前比较,治疗后2组患者TC、TG、LDL、MAP与24 h UAE水平均显著下降(P0.01),且观察组显著低于对照组(P0.05或P0.01);2组血清HDL水平均升高,且观察组高于对照组(P0.01);治疗后观察组的总有效率85.17%高于对照组的68.57%(P0.05);观察组计划外终止妊娠例数少于对照组,计划内终止妊娠例数多于对照组(P0.05);观察组终止妊娠前平均延长孕周时间显著长于对照组(P0.01),2组间产后出血量与新生儿体重差异无统计学意义(P0.05)。结论:滋阴平肝法可有效缓解PE孕妇临床症状,调节其血脂与血压水平,改善妊娠结局。

Effect of Nourishing Yin and Calming Liver Method on Blood Lipid Level and Pregnancy Outcome of Preeclampsia Pregnant Women

To explore the effect of nourishing yin and calming liver method on blood lipid level and pregnancy outcome of preeclampsia (PE) pregnant women. Methods:A total of 140 PE pregnant women in our hospital from January 2014 to December 2017 were randomly divided into observation group and control group, with 70 cases in each group. Both groups were treated with routine western medicine, and observation group was treated with nourishing yin and calming liver method on the basic of control group. 2 groups were treated continuously until delivery or termination of pregnancy. The traditional Chinese medicine (TCM) syndrome score, blood lipid levels and related indexes before and after treatment in 2 groups were compared; clinical effect and pregnancy outcome of 2 groups of pregnant women were counted. Results:Compared with before treatment, the TCM syndrome scores such as headache, vertigo, abdominal pain of 2 groups after treatment significantly decreased, and observation group was significantly lower than control group (P<0.01); Compared with before treatment, the levels of TC, TG, LDL, MAP and 24 h UAE of 2 groups after treatment decreased significantly (P<0.01), and observation group was significantly lower than control group (P<0.05 or P<0.01); The serum HDL level of 2 groups increased significantly, and observation group was higher than control group (P<0.01); The total effective rate of observation group after treatment was significantly higher than that of control group (85.17% vs 68.57, P<0.05); The number of unplanned pregnancy termination of observation group was significantly less than control group, and the number of terminations in the plan was larger than control group (P<0.05); The average duration of gestational weeks before termination of pregnancy of observation group was significantly longer than the control group (P<0.01); There was no significant difference in postpartum hemorrhage and neonatal weight between 2 groups (P>0.05). Conclusion:The nourishing yin and calming liver method can effectively relieve the clinical symptoms of PE pregnant women, regulate the level of blood lipid and blood pressure, and improve the pregnancy outcome.